The cardioprotection granted by metoprolol is restricted to its administration prior to coronary reperfusion.

International Journal of Cardiology
Borja IbanezJuan J Badimon

Abstract

Myocardial infarct size is a strong predictor of cardiovascular events. Intravenous metoprolol before coronary reperfusion has been shown to reduce infarct size; however, it is unknown whether oral metoprolol initiated early after reperfusion, as clinical guidelines recommend, is similarly cardioprotective. We compared the extent of myocardial salvage associated with intravenous pre-reperfusion-metoprolol administration in comparison with oral post-reperfusion-metoprolol or placebo. We also studied the effect on suspected markers of reperfusion injury. Thirty Yorkshire-pigs underwent a reperfused myocardial infarction, being randomized to pre-reperfusion-metoprolol, post-reperfusion-metoprolol or placebo. Cardiac magnetic resonance imaging was performed in eighteen pigs at day 3 for the quantification of salvaged myocardium. The amounts of at-risk and infarcted myocardium were quantified using T2-weighted and post-contrast delayed enhancement imaging, respectively. Twelve animals were sacrificed after 24h for reperfusion injury analysis. The pre-reperfusion-metoprolol group had significantly larger salvaged myocardium than the post-reperfusion-metoprolol or the placebo groups (31 ± 4%, 13 ± 6%, and 7 ± 3% of myocardium at-risk ...Continue Reading

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Citations

Feb 1, 2013·Revista Española De Cardiología·Leticia Fernández-FrieraBorja Ibáñez
Sep 16, 2011·Revista española de cardiología·Borja IbáñezVicente Sánchez-Brunete
Dec 1, 2015·Archives of Cardiovascular Diseases·Claire BouletiStéphane Germain
Apr 11, 2015·Journal of the American College of Cardiology·Borja IbáñezFrans Van de Werf
May 3, 2012·Annals of the New York Academy of Sciences·David Sanz-RosaBorja Ibanez
Apr 8, 2016·Journal of the American College of Cardiology·Jose M García-RuizBorja Ibáñez
Jan 13, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Geir O DahleKetil Grong
Nov 26, 2010·International Journal of Cardiology·Borja IbanezJuan J Badimon
Nov 22, 2012·International Journal of Cardiology·Saurav ChatterjeeDebabrata Mukherjee
Nov 19, 2014·Nature Reviews. Cardiology·Ryanne P BetgemNiels van Royen
Apr 19, 2017·Nature Communications·Jaime García-PrietoBorja Ibanez
May 9, 2018·Journal of Cardiovascular Pharmacology·Ioannis K RizosThomas G Parker
Jun 8, 2019·European Heart Journal. Acute Cardiovascular Care·Xavier RosselloBorja Ibanez
Oct 1, 2014·Nature Reviews. Cardiology·Valentin Fuster
Jan 20, 2017·Experimental and Therapeutic Medicine·Xianchi LiPeiying Zhang
Oct 8, 2020·European Heart Journal·Agustín Clemente-MoragónBorja Ibáñez
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guo-Bo XuShang-Gao Liao

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