The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage

Biochemical and Biophysical Research Communications
Kevin LawrenceDavid S Latchman

Abstract

We have previously shown, using Affymetrix gene chip technology, that urocortin induces the expression of several diverse genes in cardiac myocytes. An ATP sensitive inwardly rectifying potassium channel, Katp (Kir6.1), the enzyme calcium independent phospholipase A2 (iPLA2), and protein kinase C epsilon (PKCepsilon) and that these genes are involved in the cardioprotective mechanism of action of urocortin. Here we demonstrate that these gene products are localized to cardiac myocyte mitochondria and for the first time show that urocortin protects cardiac myocytes from ischaemia/reperfusion induced cell death by preventing mitochondrial damage. Using pharmacological agents to Katp channels and iPLA2 and synthetic peptide inhibitors of PKCepsilon, we go on to demonstrate that these three gene products are involved in the urocortin induced protection of cardiac myocyte mitochondria. These proteins may interact at the mitochondria to produce the protective effect.

References

Feb 1, 1991·Journal of Molecular and Cellular Cardiology·N A BurnashevL V Rosenshtraukh
Oct 1, 1994·The Journal of General Physiology·J A Lundbaek, O S Andersen
Mar 1, 1995·Basic Research in Cardiology·G J Gross
Jan 22, 1998·Biochemical and Biophysical Research Communications·M SuzukiK Takata
Jun 25, 1998·Neuropeptides·A OkosiR A Knight
Jan 12, 2000·Molecular and Cellular Endocrinology·B K BrarD S Latchman
Nov 14, 2000·Circulation Research·B O'Rourke
Oct 13, 2001·Trends in Cardiovascular Medicine·D S Latchman
May 15, 2002·The International Journal of Biochemistry & Cell Biology·David S Latchman
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Daniel SchulmanDerek M Yellon
May 10, 2003·Journal of Molecular and Cellular Cardiology·H SinghR I Norman

❮ Previous
Next ❯

Citations

Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ji LiLawrence H Young
Feb 17, 2009·Cardiovascular Research·Derek J Hausenloy, Derek M Yellon
May 8, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Paul A TownsendAndrew P Halestrap
Dec 24, 2013·Journal of Molecular Endocrinology·Rong WanShengnan Li
Jun 22, 2011·Journal of Molecular and Cellular Cardiology·Theophilus I EmetoJonathan Golledge
Sep 27, 2008·Biochemical Pharmacology·Sean M DavidsonPaul A Townsend
Jan 9, 2008·International Journal of Cardiology·Phitsanu BoonprasertNipon Chattipakorn
Nov 7, 2006·Frontiers in Neuroendocrinology·Eva M Fekete, Eric P Zorrilla
Apr 5, 2005·British Journal of Pharmacology·Angel Luis García-VillalónGodofredo Diéguez
Oct 12, 2010·Biochemical and Biophysical Research Communications·Tomoka Takatani-Nakase, Koichi Takahashi
Jun 18, 2010·The Veterinary Journal·Gemma Fraga VelosoPauline M Jamieson
Aug 9, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Zhi-Hua WangHuang-Tian Yang
May 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sriram Ravindran, Gino A Kurian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Kevin LawrenceDavid S Latchman
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Kevin LawrenceDavid S Latchman
Molecular and Cellular Endocrinology
Bhawanjit K BrarDavid S Latchman
© 2021 Meta ULC. All rights reserved