The Cardioprotective Effect of Vitamin E (Alpha-Tocopherol) Is Strongly Related to Age and Gender in Mice

PloS One
Xiao-Xia HuJing-Song Ou

Abstract

Vitamin E (VitE) only prevented cardiovascular diseases in some patients and the mechanisms remain unknown. VitE levels can be affected by aging and gender. We hypothesize that age and gender can influence VitE's cardioprotective effect. Mice were divided into 4 groups according to age and gender, and each group of mice were divided into a control group and a VitE group. The mice were administered water or VitE for 21 days; Afterward, the cardiac function and myocardial infarct size and cardiomyocyte apoptosis were measured after myocardial ischemia reperfusion(MI/R). VitE may significantly improved cardiac function in young male mice and aged female mice by enhancing ERK1/2 activity and reducing JNK activity. Enhanced expression of HSP90 and Bcl-2 were also seen in young male mice. No changes in cardiac function and cardiac proteins were detected in aged male mice and VitE was even liked to exert a reverse effect in cardiac function in young mice by enhancing JNK activity and reducing Bcl-2 expression. Those effects were in accordance with the changes of myocardial infarction size and cardiomyocyte apoptosis in each group of mice. VitE may reduce MI/R injury by inhibiting cardiomyocyte apoptosis in young male mice and aged fem...Continue Reading

References

May 20, 1993·The New England Journal of Medicine·M J StampferW C Willett
May 20, 1993·The New England Journal of Medicine·E B RimmW C Willett
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsP Sleight
Feb 24, 2001·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·J S CoombesR A Shanely
Apr 14, 2004·Basic & Clinical Pharmacology & Toxicology·Ipseeta MohantySuresh Kumar Gupta
Aug 4, 2004·Experimental Gerontology·Sergey Kamzalov, Rajindar S Sohal
Jul 7, 2005·JAMA : the Journal of the American Medical Association·I-Min LeeJulie E Buring
Jan 9, 2007·The American Journal of Clinical Nutrition·Maret G Traber
Apr 14, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jae Ju JeongKi Churl Chang
Mar 11, 2010·American Journal of Physiology. Endocrinology and Metabolism·Zhi-Jun OuJing-Song Ou
May 31, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Fan YangYing-ying Chen
Mar 23, 2012·Circulation. Heart Failure·Claudia U ChaeJulie E Buring
May 9, 2012·Interactive Cardiovascular and Thoracic Surgery·Ramón RodrigoPablo Guzmán

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Citations

Sep 8, 2016·American Journal of Physiology. Endocrinology and Metabolism·Zhi-Jun OuJing-Song Ou
May 1, 2021·Antioxidants·José Lillo-MoyaRamón Rodrigo

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