The cardiovascular actions of protease-activated receptors

Molecular Pharmacology
S F Steinberg

Abstract

Protease-activated receptors (PARs) comprise a family of G protein-coupled receptors with a unique proteolytic activation mechanism. PARs are activated by thrombin or other coagulation or inflammatory proteases formed at sites of tissue injury. PARs play a particularly important role in the pathogenesis of clinical disorders characterized by chronic inflammation or smoldering activation of the coagulation cascade. Individual PARs have been linked to the regulation of a broad range of cellular functions. Recent studies identify PAR family members in the vasculature (including within atherosclerotic lesions) and in the heart. Here, PAR-triggered responses contribute to vasoregulation and influence cardiac electrical and mechanical activity. PAR activation also is linked to structural remodeling of the vasculature and the myocardium. This review focuses on the cardiovascular actions of PARs that play a role in normal cardiovascular physiology and that are likely to contribute to cardiovascular diseases.

References

Apr 1, 1996·Circulation Research·T JiangS F Steinberg
Jan 20, 1999·Cardiovascular Research·E A WoodcockO Binah
Jan 30, 1999·Journal of Molecular and Cellular Cardiology·T JiangS F Steinberg
Mar 4, 2000·The Journal of Biological Chemistry·G R SambranoS R Coughlin
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·C NapoliG Cirino
Jul 4, 2001·Nature Medicine·N VergnolleJ L Wallace
Aug 13, 2002·The Biochemical Journal·Steven J ComptonMorley D Hollenberg
Jan 11, 2003·The Journal of Biological Chemistry·Abdelkarim SabriSusan F Steinberg
Apr 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Christopher D MajorPatricia Andrade-Gordon
Feb 20, 2004·The Journal of Biological Chemistry·Todd M QuintonSatya P Kunapuli
Feb 21, 2004·The Journal of Pharmacology and Experimental Therapeutics·Atsufumi KawabataRobin Plevin
Feb 26, 2004·The Journal of Biological Chemistry·Matthew J LudemanShaun R Coughlin
Mar 27, 2004·Physiological Reviews·Valeria S Ossovskaya, Nigel W Bunnett

❮ Previous
Next ❯

Citations

Feb 13, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·James D Moffatt
Aug 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aaron N Snead, Paul A Insel
Apr 6, 2007·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·V G SolomonovaP V Avdonin
Aug 21, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Silvio AntoniakRafal Pawlinski
Oct 31, 2007·Circulation·Rafal PawlinskiNigel Mackman
Feb 9, 2013·The Journal of Clinical Investigation·Silvio AntoniakNigel Mackman
Jul 16, 2008·International Archives of Medicine·Manuel Menendez-GonzalezAna Suarez
Jan 17, 2008·PloS One·Jo N FlemingStephen M Schwartz
Dec 7, 2013·PloS One·Silvio AntoniakRafal Pawlinski
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Douglas J ShefflerBryan L Roth
Jul 26, 2011·Journal of Cell Communication and Signaling·David B MurrayJoseph S Janicki
Apr 22, 2015·Hämostaseologie·K Schrör
Dec 9, 2015·Journal of Molecular and Cellular Cardiology·Mikhail A KolpakovAbdelkarim Sabri
Jan 24, 2009·The International Journal of Biochemistry & Cell Biology·Andreas BillichThomas Baumruker
May 13, 2006·The Journal of Investigative Dermatology·Jean-Pierre HachemPeter M Elias
May 29, 2007·Pharmacology & Therapeutics·Elena Sokolova, Georg Reiser
Aug 12, 2014·Thrombosis and Haemostasis·Silvio AntoniakRafal Pawlinski
Dec 2, 2014·Hämostaseologie·M F Bode, N Mackman
May 6, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C AugéN Cenac
Dec 17, 2008·Journal of Thrombosis and Haemostasis : JTH·R Pawlinski, N Mackman
Mar 26, 2011·IUBMB Life·Silvio AntoniakNigel Mackman
Mar 2, 2011·Journal of Molecular Recognition : JMR·Helena C CastroCarlos R Rodrigues
Feb 18, 2006·Biochemical and Biophysical Research Communications·Fumi MomotaHideo Kanaide
Apr 14, 2016·European Heart Journal·Henri M H SpronkUlrich Schotten
Apr 15, 2015·Molecular and Cellular Endocrinology·Peter Tzu-Yu ChienChuen-Mao Yang
Nov 17, 2014·Inflammation·Sae-Kwang Ku, Jong-Sup Bae
Jan 10, 2013·Biochimica Et Biophysica Acta·Paul F Mercer, Rachel C Chambers
Mar 19, 2014·Blood·Silvio Antoniak, Nigel Mackman
Sep 20, 2016·JACC. Basic to Translational Science·Céline JumeauStéphane N Hatem
Jun 17, 2006·Current Opinion in Pharmacology·Giuseppe Cirino, Nathalie Vergnolle
Dec 10, 2008·Experimental Biology and Medicine·Vabren L Watts, Evangeline D Motley
Jun 5, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Be'eri Niego, Robert L Medcalf

❮ Previous
Next ❯

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