The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation

Clinical Epigenetics
Ting Li-TempelJonathan D Turner

Abstract

Gender, genetic makeup, and prior experience interact to determine physiological responses to an external perceived stressor. Here, we investigated the contribution of both genetic variants and promoter methylation of the NR3C1 (glucocorticoid receptor) gene to the cardiovascular and hypothalamus-pituitary-adrenal (HPA) axis response to the socially evaluated cold pressor test (seCPT). Two hundred thirty-two healthy participants were recruited and underwent the experiment. They were randomly assigned to either the seCPT group (cold water) or a control group (warm water). The seCPT group had a clear stress reaction; salivary cortisol levels and peak systolic and diastolic blood pressure all increased significantly compared to the control group. GR genotype (TthIIII, NR3C1-I, 1H, E22E, R23K, BclI and 9beta) and methylation data were obtained from 218 participants. Haplotypes were built from the GR genotypes, and haplotype 2 (minor allele of BclI) carriers had a higher cortisol response to the seCPT in comparison to non-carriers (20.77 ± 13.22; 14.99 ± 8.42; p = 0.034), as well as independently of the experimental manipulation, higher baseline heart rate (72.44 ± 10.99; 68.74 ± 9.79; p = 0.022) and blood pressure (115.81 ± 10.47; ...Continue Reading

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Citations

Apr 23, 2016·Psychoneuroendocrinology·Kumi HirokawaHiroyasu Iso
Oct 25, 2016·Diabetes/metabolism Research and Reviews·Clarissa Silva MartinsMargaret de Castro
Sep 8, 2016·Clinical Epigenetics·Fleur A D LeenenJonathan D Turner
Nov 28, 2018·Stress : the International Journal on the Biology of Stress·Ting Li-TempelAndrea B Schote
Oct 16, 2016·Development and Psychopathology·Robert-Paul JusterMartin Picard
Aug 14, 2019·Development and Psychopathology·Martha M C ElwenspoekJonathan D Turner
Oct 1, 2019·Critical Care Medicine·James A Russell, Jonathan Sevransky
Oct 6, 2019·American Journal of Hypertension·Sahul Bharti, Bhavneet Bharti
Aug 23, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Peng ZhangJi-Min Cao
Aug 31, 2019·Stress : the International Journal on the Biology of Stress·Katarina BuzgoovaDaniela Jezova
Feb 9, 2019·International Journal of Genomics·Nathalie GrovaJonathan D Turner
Dec 31, 2017·International Journal of Cardiology·Guang HaoShaoyong Su

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

R
R package “ moments ”
Haploview
PyroMark ID
obsHET
PHASE
SPSS
Pyro Q - CpG
R package Tukey
predHET

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