PMID: 7537945May 1, 1995Paper

The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia

Anesthesiology
C A LienJ J Savarese

Abstract

Atracurium consists of a mixture of ten stereoisomers. One of these isomers, 51W89, is a potent intermediate-acting nondepolarizing neuromuscular blocking agent. Its ED95 is 0.05 mg.kg-1 in patients receiving nitrous oxide/opioid anesthesia. In preclinical trials, 51W89 did not show evidence of histamine release in cats at doses up to 80 times the human ED95. This study was undertaken to determine the cardiovascular effects and histamine-releasing properties of 51W89 in patients undergoing elective surgical procedures. Sixty patients, ASA physical status 1 or 2, anesthetized with nitrous oxide/fentanyl/thiopental were studied. Patients received either 2 times the ED95 of atracurium or 51W89 or 4 or 8 times the ED95 of 51W89 as a rapid intravenous bolus under stable anesthesia, before surgical stimulation. Blood pressure and heart rate were measured by oscillometry and the electrocardiogram in patients receiving 2 times the ED95 of 51W89 or atracurium and by an intraarterial catheter and a tachograph triggered by the arterial pulse waveform in patients receiving 4 or 8 times the ED95 of 51W89. Maximal blood pressure and heart rate changes during the 5 min after administration of the muscle relaxant were recorded. Venous blood sa...Continue Reading

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Citations

Jul 1, 1997·Journal of Clinical Pharmacology·V D SchmithT H Grasela
Sep 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·L S BluesteinR M Wilson
Jul 11, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T M HemmerlingH Schwilden
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Aug 24, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Giorgio ContiRodolfo Proietti
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Oct 4, 2006·Current Opinion in Anaesthesiology·M Leuwer
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Jan 22, 2013·Pulmonary Pharmacology & Therapeutics·Paola RoglianiMaria Gabriella Matera
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Aug 24, 2021·Frontiers in Immunology·Benjamin D McNeil

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