The cardiovascular effects of atracurium and it's metabolite

Journal of Anesthesia
K FukushimaH Nagashima

Abstract

The administration of atracurium to humans has been reported to produce little cardiovascular effects in clinical doses. The cardiovascular effect, histamine-releasing and catecholamine releasing effects of intravenous injection of atracurium 0.6 and 1.2 mg.kg(-1) were studied in man, and also the cardiovascular and catecholamine releasing effects of laudanosine which is a metabolite of atracurium by Hofmann degeneration, were studied in dogs. The increase in human plasma concentration of histamine, hypotension and tachycardia were found with the dose of atracurium 1.2 mg.kg(-1). The intravenous administration of laudanosine 10 micro g.kg(-1) to dogs produced minimal epinephrine, norepinephrine releases and cardiovascular changes.

References

Jun 1, 1989·British Journal of Anaesthesia·M KinjoE S Vizi
Jul 1, 1986·Anesthesiology·P J HennisR D Miller
Jan 1, 1981·British Journal of Anaesthesia·R Hughes, D J Chapple
Jan 1, 1981·British Journal of Anaesthesia·J P Payne, R Hughes

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