PMID: 9293Jan 1, 1975

The cardiovascular effects of etilefrine

European Journal of Clinical Pharmacology
A J ColemanA C Asmal

Abstract

Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Peripheral vascular resistance falls during the infusion of 1-8 mg etilefrine but begins to rise at higher dosage. Marked falls in pulse rate, cardiac output, stroke volume and peripheral bloodflow, accompanied by rises in mean arterial pressure, occur when etilefrine is infused after administration of intravenous propranolol 2,5 mg. These findings indicate that etilefrine has both beta 1 and alpha adrenergic effects in man.

Citations

Dec 19, 1975·European Journal of Clinical Pharmacology·J H HengstmannH J Dengler
Feb 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M Hohmann, W Künzel
Oct 1, 1994·Pharmaceutica acta Helvetiae·M P PinelS Risco
Nov 1, 1984·Clinical and Experimental Pharmacology & Physiology·S A Adigun, P H Fentem
May 27, 2008·British Journal of Pharmacology·J R Docherty
Jul 4, 2020·Journal of Pharmacological and Toxicological Methods·Yoshiko OkaiTadahiro Shinozawa
Jan 14, 2021·Drug Testing and Analysis·Fernando X MoreiraMaria de Lourdes Bastos

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