The cardiovascular effects of premature ovarian failure

International Journal of Cardiology
Hikmet YorgunKudret Aytemir

Abstract

Previous studies have shown that cardiovascular risk is increased in premature ovarian failure (POF). To determine the effects of POF on different parameters of cardiovascular health, we investigated the relationship between POF and circulating endothelial progenitor cells (EPC), endothelial function, carotid intima media thickness (CIMT) and left ventricular diastolic function. We compared 23 female POF patients (mean age; 37.8 ± 10.8 years) with 20 gender and age-matched healthy controls. Circulating CD133(+)/34(+) and CD34(+)/KDR(+) EPCs were determined by using flow-cytometry. Ultrasound assessment of endothelial function by brachial artery flow-mediated dilatation (FMD) and CIMT was made. Left ventricular systolic and diastolic function was assessed by standard 2D and M-mode echocardiography and tissue Doppler velocities. Brachial artery FMD was significantly impaired in patients with POF compared with CG (6.3 ± 1.9% vs 10.4 ± 3.7%, p<0.05). Furthermore, circulating EPCs were lower among patients with POF compared to controls for CD133(+)/34(+) and CD34(+)/KDR(+) cells (p<0.05). There was a significant correlation between serum estradiol levels and EPC number (CD 133+/34+) (r=0.329, p<0.05). POF patients had increased CIMT...Continue Reading

References

Mar 16, 1996·Lancet·Y T van der SchouwJ D Banga
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Jun 17, 2004·Circulation·Jean Davignon, Peter Ganz
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Sophia N KalantaridouLampros K Michalis
Aug 16, 2008·Basic Research in Cardiology·Stefanie KeymelChristian Heiss
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Jan 21, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takahiro MoriTsutomu Imaizumi
Mar 23, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aysun Aybal KutlugünMustafa Arici
Oct 5, 2011·Seminars in Reproductive Medicine·Melissa Wellons
Oct 26, 2011·Journal of Ovarian Research·Afshin MohammadiMohammad Ghasemi-Rad

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Citations

May 27, 2015·Maturitas·Suzette E Elias-SmaleAngela H E M Maas
Dec 18, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·M J van den BergY T van der Schouw
Apr 20, 2016·Journal of Endocrinological Investigation·A Podfigurna-StopaB Meczekalski
Jan 19, 2017·Scandinavian Cardiovascular Journal : SCJ·Muhammed Necati Murat AksoyHuseyin Gunduz
Apr 28, 2020·Headache·Marzieh Eghtesadi, Guillaume Marquis-Gravel
Jun 15, 2016·The Journal of Clinical Endocrinology and Metabolism·Nadine M P DaanBart C J M Fauser
Feb 19, 2015·Menopause : the Journal of the North American Menopause Society·Hugh S Taylor
Sep 8, 2020·Expert Review of Endocrinology & Metabolism·Miriam Giordano Imbroll, Mark Gruppetta
Apr 4, 2021·International Journal of Molecular Sciences·Daniele SantiManuela Simoni
Jun 7, 2021·BMC Pregnancy and Childbirth·Jiaman WuJilong Yao

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