The cardiovascular effects of quipazine are mediated by peripheral 5-HT2 and 5-HT3 receptors in anaesthetized rats

European Journal of Pharmacology
C Vayssettes-CourchayH Schmitt

Abstract

Quipazine (0.5-2 mg/kg i.v.) produced transient hypotension and bradycardia followed by sustained hypertension and variable effects on heart rate in anaesthetized rats. The hypotension, bradycardia and sympatho-inhibitory effects of quipazine were attenuated by bivagotomy. In bivagotomized rats, the hypertension produced by quipazine was not modified by hexamethonium or prazosin but was abolished by ritanserin (1 mg/kg i.v.). In ritanserin-treated rats, section of the carotid sinus nerves and vagus nerves or ICS 205.930 (0.1 mg/kg i.v.) abolished the hypotensive, bradycardic and sympatho-inhibitory effects of quipazine; the action of quipazine was not reproducible in these rats. Quipazine also inhibited the Bezold-Jarish reflex elicited by 5-HT (20 micrograms/kg i.v.). In ICS 205.930-treated rats, the hypertension evoked by quipazine was associated with a reduction in splanchnic nerve activity due to stimulation of baroreceptors. The renin-angiotensin system is not involved in the hypertensive response. The increase in heart rate produced by quipazine in bivagotomized rats was reduced by ritanserin and tertatolol (0.1 mg/kg i.v.) and abolished by a combination of both drugs. We conclude that the bradycardic and sympatho-inhibit...Continue Reading

References

Mar 1, 1977·Pharmacology, Biochemistry, and Behavior·J B MalickA Barnett
Jan 1, 1978·Endocrine Research Communications·R W FullerJ A Clemens
Oct 1, 1976·Life Sciences·H Y MeltzerR Kaluskar
Jul 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·M HamonJ Glowinski
May 1, 1976·Life Sciences·R W FullerD T Wong
Jan 1, 1990·Journal of Cardiovascular Pharmacology·M H ZinkR H Alper
Oct 1, 1988·British Journal of Pharmacology·G HewsonJ Hughes
Jun 22, 1988·European Journal of Pharmacology·R B McCall, L T Harris
Nov 1, 1973·European Journal of Pharmacology·R RodríguezR R Drucker-Colín
Jan 1, 1969·European Journal of Pharmacology·E HongE G Pardo

❮ Previous
Next ❯

Citations

Feb 12, 1997·European Journal of Pharmacology·C Vayssettes-CourchayT J Verbeuren
Jun 24, 2010·Journal of Cardiovascular Pharmacology·João Xavier de Araújo JúniorEliezer Jesus Barreiro
Apr 1, 1995·British Journal of Pharmacology·D L DownieN M Barnes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.