The cardiovascular response to digoxin in conscious dogs with left atrial obstruction

Journal of Cardiothoracic Anesthesia
P M Heerdt, R W Caldwell


In addition to positive inotropic and atrioventricular conduction-blocking properties, digoxin is capable of producing systemic and pulmonary vasoconstriction. However, whether chronic digoxin treatment exacerbates the pulmonary hypertension that results from left atrial (LA) outflow obstruction has not been specifically examined. This study assessed the vascular and inotropic responses to 5 days of digoxin treatment in six conscious dogs before and after filling a permanently implanted LA balloon. Dogs were also instrumented to measure left ventricular (LV) pressure, LV dP/dt, mean systemic arterial (MAP), right atrial (RAP), pulmonary arterial, and pulmonary capillary wedge pressures, as well as cardiac output (CO). Under normal conditions with the balloon empty, digoxin treatment (40 micrograms/kg loading dose and 12 micrograms/kg/d for 5 days) reduced CO (-17%) and increased systemic (SVR) and pulmonary (PVR) vascular resistances 27% and 37%, respectively; heart rate (HR) and LV dP/dt were not changed. Filling the balloon with enough saline to double PVR also increased SVR (52%), HR (42%), and RAP (92%), and reduced CO (-24%). During LA outflow obstruction, 5 days of digoxin reduced HR (-17%), SVR (-29%), and RAP (-23%), bu...Continue Reading


Sep 1, 1985·Journal of Cardiovascular Pharmacology·T E MeccaR W Caldwell
May 1, 1985·Journal of the American College of Cardiology·F L Meijler
May 1, 1985·Journal of the American College of Cardiology·J C Longhurst, J Ross
Sep 1, 1973·Circulation·R J Linden
Sep 1, 1968·American Heart Journal·L M LindeG Sarna
Oct 1, 1969·Circulation·F P HeidenreichJ J Leonard
May 1, 1953·Circulation Research·F J HADDYI D BARONOFSKY
Apr 1, 1964·The Journal of Physiology·J R LEDSOME, R J LINDEN
Nov 1, 1964·Progress in Cardiovascular Diseases·L WERKOE

❮ Previous
Next ❯


Sep 1, 1992·Journal of Clinical Anesthesia·P M Heerdt, M E Heerdt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.