The cardiovascular risk factor, soluble CD40 ligand (CD154), but not soluble CD40 is lowered by ultra-endurance exercise in athletes

British Journal of Sports Medicine
Liesel GeertsemaLiam J Fernyhough

Abstract

Soluble CD40 ligand (sCD40L) is a powerful marker of cardiovascular risk. Exercise is known to decrease cardiovascular risk, but the impact of ultra-endurance exercise on sCD40L responses is unknown. To examine the relationship between ultra-endurance exercise in trained athletes and levels of sCD40L and its natural ligand sCD40. Control-trial, crossover design, exercise intervention study of sCD40L and sCD40 levels. Outdoor exercise and laboratory testing, single centre study, School of Physical Education, University of Otago, New Zealand. Nine trained ultra-endurance athletes. Athletes exercised (cycled and jogged) for 17 of 24 h. Venous blood was sampled at baseline and serially throughout exercise and 24 and 48 h after exercise. The athletes completed a 24 h control trial on a separate occasion, in randomised order. Mean levels of sCD40L and sCD40 during exercise and rest with 95% CIs. sCD40L levels dropped steadily from baseline (median 4128 pg/ml) to a measured nadir at 24 h following exercise (median 1409 pg/ml) (p=0.01). The levels had started to rise again by 48 h after exercise. When measured as a group, sCD40L levels remained constant during a control rest period. sCD40 levels remained constant on both exercise and c...Continue Reading

Citations

Apr 1, 2006·Cellular Immunology·Daniel Rodríguez-Pinto
Jul 26, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Mohammed Andaleeb ChowdhuryLijun C Liu

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