The cardiovascular risk profile of middle age women previously diagnosed with premature ovarian insufficiency: A case-control study

PloS One
Marlise N GunningCREW consortium

Abstract

Cardiovascular disease (CVD) is the leading cause of death in women worldwide. The cardiovascular risk profile deteriorates after women enter menopause. By definition, women diagnosed with premature ovarian insufficiency (POI) experience menopause before 40 years of age, which may render these women even more susceptible to develop CVD later in life. However, prospective long-term follow up data of well phenotyped women with POI are scarce. In the current study we compare the CVD profile and risk of middle aged women previously diagnosed with POI, to a population based reference group matched for age and BMI. We compared 123 women (age 49.0 (± 4.3) years) and diagnosed with POI 8.1 (IQR: 6.8-9.6) years earlier, with 123 population controls (age 49.4 (± 3.9) years). All women underwent an extensive standardized cardiovascular screening. We assessed CVD risk factors including waist circumference, BMI, blood pressure, lipid profile, pulse wave velocity (PWV), and the prevalence of diabetes mellitus, metabolic syndrome (MetS) and carotid intima media thickness (cIMT), in both women with POI and controls. We calculated the 10-year CVD Framingham Risk Score (FRS) and the American Heart Association's suggested cardiovascular health sc...Continue Reading

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Citations

Aug 19, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ali OvayoluAntonio Cianci
Jan 30, 2021·Seminars in Reproductive Medicine·Izaäk Schipper, Yvonne V Louwers
Jun 26, 2021·Climacteric : the Journal of the International Menopause Society·J C StevensonN Panay

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Methods Mentioned

BETA
bilateral oophorectomy

Clinical Trials Mentioned

NCT02309047
NCT02616510

Software Mentioned

Statistical Package for Social Sciences ( SPSS )
R

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