The CARMA Study: Early Infant Antiretroviral Therapy-Timing Impacts on Total HIV-1 DNA Quantitation 12 Years Later.

Journal of the Pediatric Infectious Diseases Society
Caroline FosterPablo Rojo Conejo

Abstract

Strategies aimed at antiretroviral therapy (ART)-free remission will target individuals with a limited viral reservoir. We investigated factors associated with low reservoir measured as total human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood mononuclear cells (PBMCs) in perinatal infection (PaHIV). Children from 7 European centers in the Early Treated Perinatally HIV Infected Individuals: Improving Children's Actual Life (EPIICAL) consortium who commenced ART aged <2 years, and remained suppressed (viral load [VL] <50 copies/mL) for >5 years were included. Total HIV-1 DNA was measured by quantitative polymerase chain reaction per million PBMCs. Factors associated with total HIV-1 DNA were analyzed using generalized additive models. Age, VL at ART initiation, and baseline CD4% effects were tested including smoothing splines to test nonlinear association. Forty PaHIV, 27 (67.5%) female 21 (52.5%) Black/Black African, had total HIV-1 DNA measured; median 12 (IQR, 7.3-15.4) years after ART initiation. Eleven had total HIV-1 DNA <10 copies/106 PBMCs. HIV-1 DNA levels were positively associated with age and VL at ART initiation, baseline CD4%, and Western blot antibody score. Age at ART initiation presented a linear...Continue Reading

References

Mar 16, 2013·Medicina clínica·Alfredo Tagarro
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Aug 28, 2014·Frontiers in Immunology·Maximilian MuenchhoffPhilip Jeremy Renshaw Goulder
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May 10, 2017·The Lancet. HIV·Jemma O'ConnorUNKNOWN UK Collaborative HIV Cohort (CHIC) Study
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Jun 30, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alfredo TagarroUNKNOWN EPIICAL Consortium
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Feb 12, 2019·AIDS·UNKNOWN European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) and Early-treated Perinatally HIV-infected Individuals:

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Citations

Jan 26, 2021·Journal of the Pediatric Infectious Diseases Society·Sara Domínguez-RodríguezPablo Rojo
Jul 9, 2021·Journal of the International AIDS Society·Margherita DoriaUNKNOWN EPIICAL consortium

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Software Mentioned

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