The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

Cytotechnology
Murat BakırMirkhalil Hosseinigouzdagani

Abstract

Acute pancreatitis (AP) may cause significant persistent multi-organ dysfunction. Carvacrol (CAR) possesses a variety of biological and pharmacological properties. The aim of the present study was to analyze the hepatic protection of CAR on AP induced by cerulein and to explore the underlying mechanism using in vivo studies. The rats were randomized into groups to receive (1) no therapy; (2) 50 µg/kg cerulein at 1-h intervals by four intraperitoneal injection (i.p.); (3) 50, 100 and 200 mg/kg CAR by one i.p.; and (4) cerulein + CAR after 2 h of cerulein injection. 12 h later, serum was provided to assess the blood AST, ALT and LDH values. Also, liver tissues were obtained for histological and biochemical measurements. Liver oxidative stress markers were evaluated by changes in the amount of lipid peroxides measured as MDA and changes in tissue antioxidant enzyme levels, SOD, CAT and GSH-Px. Histopathological examination was performed using scoring systems. Oxidative damage to DNA was quantitated in studied tissues of experimental animals by measuring the increase in 8-hydroxydeoxyguanosine (8-OHdG) formations. We found that the increasing doses of CAR decreased pancreatitis-induced MDA and 8-OH-dG levels. Moreover, the liver SO...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·A M RappaportM J Phillips
Jul 13, 2000·Bioorganic & Medicinal Chemistry Letters·G M CingolaniF Claudi
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Jan 28, 2004·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Samia IjazAlexander M Seifalian
Dec 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F M El-DemerdashN I Abou El-Naga
Aug 16, 2005·Nitric Oxide : Biology and Chemistry·Tomohiro Sawa, Hiroshi Ohshima
May 23, 2006·Journal of Ethnopharmacology·K ElhabaziA Dalal
Dec 6, 2007·Journal of Clinical Gastroenterology·Jaime Bosch
Oct 8, 2008·Antioxidants & Redox Signaling·Po Sing Leung, Yuk Cheung Chan
Oct 25, 2008·Shock·Satoshi HagiwaraTakayuki Noguchi
May 30, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·U UndeğerN Başaran
Jul 7, 2009·Journal of Lipid Research·Mariko HottaHiroyasu Inoue
Aug 5, 2009·Fundamental & Clinical Pharmacology·Balakrishnan AristatileKodukkur Viswanathan Pugalendi
Sep 29, 2009·International Journal of Pharmaceutics·S HeukingG Borchard
Mar 25, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seyyed Siavash Saei-DehkordiFarahnaz Khalighi-Sigaroodi
Jun 15, 2010·Toxicology and Industrial Health·Hasan Türkez, Başak Toğar
Jun 24, 2010·Journal of Agricultural and Food Chemistry·Samia AyariMonique Lacroix
Nov 1, 2008·Environmental Toxicology and Pharmacology·Fatime Geyikoglu, Hasan Turkez
Sep 1, 2011·Molecular and Cellular Biochemistry·Subramaniyan JayakumarThiruvengadam Devaki
Aug 16, 2012·Journal of Medicinal Food·Francilene V SilvaRita C M Oliveira
Jan 1, 2013·Bioorganic & Medicinal Chemistry Letters· BeenaDiwan S Rawat
May 3, 2013·Wiener klinische Wochenschrift·Elisabeth FabianLajos Attila Réthy
Oct 17, 2013·Bulletin of Experimental Biology and Medicine·L M NepomnyashchikhS I Protsenko
Nov 21, 2013·World Journal of Transplantation·Suomi Mg FouraschenJeroen de Jonge
Mar 22, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Catherine J YangMaxim S Petrov
Apr 2, 2014·Srpski arhiv za celokupno lekarstvo·Tomislav TasićDanijela Benedeto-Stojanov
Apr 8, 2014·Diagnostic and Interventional Imaging·A TürkvatanG Yüce
Apr 12, 2014·The Journal of Surgical Research·Hiroaki ShibaDympna M Kelly

❮ Previous
Next ❯

Citations

May 18, 2016·Oxidative Medicine and Cellular Longevity·Seyed Abbas MirmalekEhsan Jangholi
Mar 16, 2017·Phytotherapy Research : PTR·Pratibha AnchiChandraiah Godugu
Jan 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xin ZhaoHuayi Suo
Jan 27, 2018·Journal of Translational Medicine·Ajaikumar B KunnumakkaraBharat B Aggarwal
May 11, 2018·Phytotherapy Research : PTR·Mehdi Sharifi-RadJavad Sharifi-Rad
Nov 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu QianWeiwei Liu
May 14, 2021·Frontiers in Pharmacology·Bahare SalehiJavad Sharifi-Rad
May 25, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Alireza MortazaviMahmoud Hosseini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.