The Case for BPA as an Obesogen: Contributors to the Controversy

Frontiers in Endocrinology
Beverly S RubinAna M Soto

Abstract

Since the inception of the term endocrine disruptor, the idea that the environment is an important determinant of phenotype has motivated researchers to explore the effect of low dose exposure to BPA during organogenesis. The syndrome observed was complex, affecting various endpoints such as reproduction and reproductive tissues, behavior, mammary gland development and carcinogenesis, glucose homeostasis, and obesity. This constellation of impacted endpoints suggests the possibility of complex interactions among the multiple effects of early BPA exposure. One key finding of our rodent studies was alterations of energy and amino-acid metabolism that were detected soon after birth and continued to be present at all time points examined through 6 months of age. The classical manifestations of obesity and associated elements of metabolic disease took a longer time to become apparent. Here we examine the validity of the often-mentioned lack of reproducibility of obesogenic effects of BPA, starting from the known environmental causes of variation, which are diverse and range from the theoretical like the individuation process and the non-monotonicity of the dose-response curve, to the very pragmatic like housing, feed, and time and r...Continue Reading

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Citations

Jan 26, 2020·International Journal of Environmental Research and Public Health·Katarina BaralićDanijela Đukić-Ćosić
Sep 19, 2019·Journal of the Endocrine Society·Melanie H JacobsonLeonardo Trasande
Jan 17, 2020·International Journal of Environmental Research and Public Health·Lidia CaporossiBruno Papaleo
Dec 19, 2020·International Journal of Environmental Research and Public Health·Brigitte Le Magueresse-Battistoni
Jun 3, 2021·International Journal of Molecular Sciences·Isabel C CohenSonya M Schuh
Aug 20, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Tim Lobstein, Kelly D Brownell

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Methods Mentioned

BETA
nuclear magnetic resonance

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