The case for xenotransplantation

Clinical Transplantation
David K C Cooper

Abstract

The availability of organs and cells from deceased humans for transplantation is not meeting the demand. Xenotransplantation, specifically the transplantation of organs and cells from genetically engineered pigs, could resolve this problem. Diabetic monkeys have remained normoglycemic and insulin-independent after pig islet transplantation for >one yr, and a pig heterotopic (non-life-supporting) heart transplant recently reached the one-yr milestone in a baboon. With these encouraging results, why is it that, with some notable exceptions, research into xenotransplantation has received relatively little support by industry, government funding agencies, and medical charitable foundations? Industry appears reluctant to support research that will take more than two to three yr to come to clinical trial, and the funding agencies appear to have been "distracted" by the current appeal of stem cell technology and regenerative medicine. It has only been the willingness of living donors to provide organs that has significantly increased the number of transplants being performed worldwide. These altruistic donations are not without risk of morbidity and even mortality to the donor. Although with the best of intentions, we are therefore tr...Continue Reading

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Citations

Nov 10, 2015·Expert Review of Clinical Immunology·David Kc Cooper, Rita Bottino
Jan 28, 2016·Xenotransplantation·David K C CooperRita Bottino
Jan 21, 2016·The Annals of Thoracic Surgery·Raghav MurthyDavid K C Cooper
Sep 15, 2015·The Journal of Pathology·David K C CooperDavid Ayares
Mar 5, 2016·Glycobiology·David K C Cooper
May 26, 2020·Xenotransplantation·Antonia W Godehardt, Ralf R Tönjes
Jul 6, 2016·Transplantation·Zheng-Yu WangA Joseph Tector
Jul 9, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Alais M Dall AgnolAlice Fernandes Alfieri
Sep 21, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D K C Cooper
Dec 5, 2016·Kidney International·Martin WijkstromDavid K C Cooper

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