The Case of Ketamine Allergy

Clinical Practice and Cases in Emergency Medicine
William BylundMaxwell Cooper

Abstract

Ketamine is often used for pediatric procedural sedation due to low rates of complications, with allergic reactions being rare. Immediately following intramuscular (IM) ketamine administration, a three-year-old female rapidly developed facial edema and diffuse urticarial rash, with associated wheezing and oxygen desaturation. Symptoms resolved following treatment with epinephrine, dexamethasone and diphenhydramine. This case presents a clinical reaction to ketamine consistent with anaphylaxis due to histamine release, but it is uncertain whether this was immunoglobulin E mediated. This is the only case reported to date of allergic reaction to IM ketamine, without co-administration of other agents.

Citations

Jan 7, 2021·Allergy and Asthma Proceedings·Timothy G ChowMin Jung Lee
Jun 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiang XieHuan Chen
Jun 25, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·U GergsJoachim Neumann

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Methods Mentioned

BETA
sedation

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