The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea

British Journal of Pharmacology
K M LulichM P Sparrow

Abstract

1 A new in vitro preparation, the isolated lung strip of the cat, is described for investigating the direct effect of drugs on the smooth muscle of the peripheral airways of the lung. The preparation comprises a thin strip of lung parenchyma which can be mounted in a conventional organ bath for isometric tension recording. Its pharmacological responses have been characterized and compared with the isolated tracheal preparation of the cat. 2 The lung strip exhibited an intrinsic tone which was relaxed by catecholamines, aminophylline and flufenamate. It was contracted strongly by histamine, prostaglandin F2alpha, acetylcholine, compound 48/80, potassium depolarizing solution and alternating current field stimulation. In contrast, the cat trachea was unresponsive to histamine and prostaglandin F2alpha and did not exhibit an intrinsic tone. 3 (-)-Isoprenaline and (-)-adrenaline were much more potent in relaxing the lung strip than the trachea. The potency order of relaxation responses to isoprenaline, adrenaline and (+/-)-noradrenaline in the lung strip was isoprenaline greater than adrenaline greater than noradrenaline but in the trachea was isoprenaline greater than noradrenaline greater than or equal to adrenaline. 4 beta2-Adre...Continue Reading

References

Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks
Jan 1, 1970·The Journal of Pharmacy and Pharmacology·J B Farmer, R A Coleman
Apr 21, 1972·Nature·J W BlackE M Parsons
Feb 10, 1967·Annals of the New York Academy of Sciences·R F Furchgott
Feb 1, 1970·The American Journal of Physiology·J H FleischB B Brodie
Nov 1, 1967·European Journal of Pharmacology·L A Chahl, S R O'Donnell
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jan 1, 1963·Physiological Reviews·J G WIDDICOMBE

Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·A P Greefhorst, C L van Herwaarden
Oct 1, 1982·European Journal of Clinical Pharmacology·C G Löfdahl, N Svedmyr
Dec 1, 1987·Inflammation·P SiroisM Lauzière
Dec 1, 1985·Agents and Actions·P O Ogunbiyi, P Eyre
Apr 1, 1978·Agents and Actions·N Chand, P Eyre
Apr 1, 1978·Agents and Actions·N Chand, P Eyre
May 1, 1981·Agents and Actions·P Eyre, K B Mirbahar
Jul 1, 1977·Agents and Actions·N Chand, P Eyre
Oct 1, 1979·Agents and Actions·K Forsberg, L Sörenby
Oct 1, 1984·Agents and Actions·A G StewartM R Fennessy
Dec 1, 1981·Agents and Actions·B B VargaftigR C Murphy
Jul 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·I PaegelowU Wartner
Oct 1, 1977·European Journal of Pharmacology·N Chand, P Eyre
May 1, 1979·European Journal of Pharmacology·J M DrazenC S Venugopalan
Feb 15, 1979·European Journal of Pharmacology·P K SieglR F Orzechowski
Feb 15, 1979·European Journal of Pharmacology·H W Mitchell, M A Denborough
Sep 11, 1981·European Journal of Pharmacology·B B Vargaftig, J Lefort
Feb 5, 1982·European Journal of Pharmacology·A MukhopadhyayD R Feller
Jul 30, 1982·European Journal of Pharmacology·G H ApperleyA T Sullivan
Jan 8, 1982·European Journal of Pharmacology·B Ek, B Lundgren
Jan 28, 1983·European Journal of Pharmacology·A J TurnerJ Shaw
Nov 27, 1984·European Journal of Pharmacology·C A Gruetter, S M Lemke
Apr 13, 1984·European Journal of Pharmacology·C Advenier, A Floch-Saint-Aubin
Sep 3, 1984·European Journal of Pharmacology·K G MugridgeS Moncada
Jan 13, 1984·European Journal of Pharmacology·E J MorcilloJ Esplugues
Feb 17, 1984·European Journal of Pharmacology·K S VincencJ Shaw
Jan 15, 1985·European Journal of Pharmacology·R G Chess-Williams, K J Broadley
Sep 2, 1987·European Journal of Pharmacology·M M Dale, A W Obianime
Jun 5, 1992·European Journal of Pharmacology·T SugasawaA D Strosberg
Dec 15, 1992·European Journal of Pharmacology·P NormanP J Gardiner
Nov 23, 1992·European Journal of Pharmacology·S A SilbaughJ H Fleisch
Dec 7, 1993·European Journal of Pharmacology·A F RoffelJ Zaagsma
Dec 12, 1994·European Journal of Pharmacology·P NormanP J Gardiner
Dec 1, 1979·Respiration Physiology·S F DuaneD E Niewoehner
Oct 1, 1995·Respiration Physiology·S B SigurdssonN L Stephens
Dec 1, 1980·Prostaglandins and Medicine·P SiroisG Girard
Oct 1, 1986·Immunopharmacology·P F SmithM Halonen
Jan 1, 1989·Pharmacology & Therapeutics·P J Gardiner
Jan 1, 1990·Pharmacology & Therapeutics·R G GoldieK M Lulich
Mar 1, 1982·Journal of the Autonomic Nervous System·J M Doidge, D Satchell
Jan 1, 1982·International Journal of Immunopharmacology·K B Mirbahar, P Eyre
Jan 1, 1979·General Pharmacology·N ChandL P Phaneuf
Jan 1, 1980·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·J M Doidge, D Satchell
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·D Satchell
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A WartonJ W Paterson
Sep 1, 1992·Journal of Pharmacological and Toxicological Methods·L H Johansson
Nov 1, 1993·Journal of Pharmacological and Toxicological Methods·A R Hulsmann, J C de Jongste
Feb 26, 2000·European Journal of Pharmacology·M Richter, P Sirois
Dec 5, 1998·Respiration Physiology·J López-Aguilar, P V Romero
Feb 1, 1982·Prostaglandins, Leukotrienes, and Medicine·J L CopasP J Gardiner
May 1, 1979·Clinical and Experimental Pharmacology & Physiology·H W Mitchell, M A Denborough
Jan 1, 1985·Clinical and Experimental Pharmacology & Physiology·C L ArmourN Berend
Dec 1, 1977·British Journal of Pharmacology·H W Mitchell, M P Sparrow
Jan 1, 1990·British Journal of Pharmacology·P J Henry, R G Goldie
Oct 1, 1981·Acta Physiologica Scandinavica·M Vornanen, R Tirri
Oct 1, 1979·The Journal of Pharmacy and Pharmacology·N Chand, L DeRoth
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·F G SalernoM S Ludwig
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·M DolhnikoffM S Ludwig
Jan 1, 1983·European Journal of Clinical Pharmacology·A P Greefhorst, C L van Herwaarden
Jun 1, 1978·The Journal of Clinical Investigation·J M Drazen, M W Schneider
Apr 1, 1986·Environmental Health Perspectives·M G BuckJ H Wall
Jan 1, 1988·Experimental Lung Research·J L Szarek, J N Evans
Aug 1, 1981·Experimental Lung Research·J N Evans, K B Adler
May 1, 2009·The Journal of Physiology·Letitia A WeigandBradley J Undem
Jan 14, 2004·British Journal of Pharmacology·Kiyoto SakataMagnus Bäck
Oct 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Prié, P Sirois
Jan 1, 1981·Thrombosis Research·J SpławińskiE Marcinkiewicz
May 1, 1989·The Journal of Pharmacy and Pharmacology·M L Candenas, E Anselmi
Aug 1, 1982·British Journal of Pharmacology·R G GoldieJ L Wale
Aug 1, 1982·British Journal of Pharmacology·R G GoldieJ L Wale
May 1, 1983·British Journal of Pharmacology·R G GoldieJ L Wale
Oct 1, 1985·British Journal of Pharmacology·C Advenier, J L Freslon
Nov 1, 1987·British Journal of Pharmacology·J RandonB B Vargaftig
Jul 30, 2004·American Journal of Veterinary Research·Changaram S VenugopalEarnestine P Holmes
Dec 1, 1983·Journal of Autonomic Pharmacology·O P AgarwalS C Manchanda
Sep 1, 1983·British Journal of Pharmacology·R A Nayler, M P Sparrow
Aug 1, 1989·Postgraduate Medical Journal·P J Barnes
Feb 1, 1985·British Journal of Pharmacology·L C Blaber, A D Fryer
Oct 1, 1982·The Journal of Pharmacy and Pharmacology·M H Hawthorn, K J Broadley
Sep 1, 1983·British Journal of Pharmacology·J F BertramJ W Paterson
Jan 1, 1987·Clinical and Experimental Pharmacology & Physiology·C L ArmourN Berend
Oct 1, 1987·The Journal of Pharmacy and Pharmacology·K TomiokaK Murase
Sep 1, 1984·The Journal of Pharmacy and Pharmacology·P F Grassby, K J Broadley
May 1, 1985·British Journal of Pharmacology·M J FinneyC G Persson
Sep 1, 1984·British Journal of Pharmacology·J CortijoM Perpiñá
Jun 1, 1979·Zentralblatt für Veterinärmedizin. Reihe A·L de Roth, N Chand
May 1, 1980·The Journal of Pharmacy and Pharmacology·G A McPhersonC Raper
Oct 12, 1999·Journal of Applied Physiology·F PetákP D Sly
Apr 1, 1984·British Journal of Pharmacology·R G GoldieJ L Wale
Sep 1, 1995·Journal of Anesthesia·Tat-Leang LeeShan S Ratnam
Nov 1, 1980·British Journal of Clinical Pharmacology·C DavisJ K Greenacre
Apr 1, 1980·British Journal of Pharmacology·D IakovidisC Raper
Jul 1, 1978·The Journal of Pharmacy and Pharmacology·N Chand, P Eyre
Jul 9, 1998·Journal of Applied Physiology·F G Salerno, M S Ludwig

Related Concepts

Adrenergic beta-Agonists
Anaphylaxis
Metazoa
Ascaris
Felis catus
Lung
Inotropism
Autacoids
Trachea
In Vitro [Publication Type]

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Ascariasis

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Ascariasis (ASM)

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.