The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis

Nature
Y ZhangS Cole

Abstract

Tuberculosis is responsible for one in four of all avoidable adult deaths in developing countries. Increased frequency and accelerated fatality of the disease among individuals infected with human immunodeficiency virus has raised worldwide concern that control programmes may be inadequate, and the emergence of multidrug-resistant strains of Mycobacterium tuberculosis has resulted in several recent fatal outbreaks in the United States. Isonicotinic acid hydrazide (isoniazid, INH) forms the core of antituberculosis regimens; however, clinical isolates that are resistant to INH show reduced catalase activity and a relative lack of virulence in guinea-pigs. Here we use mycobacterial genetics to study the molecular basis of INH resistance. A single M. tuberculosis gene, katG, encoding both catalase and peroxidase, restored sensitivity to INH in a resistant mutant of Mycobacterium smegmatis, and conferred INH susceptibility in some strains of Escherichia coli. Deletion of katG from the chromosome was associated with INH resistance in two patient isolates of M. tuberculosis.

References

Mar 15, 1992·The New England Journal of Medicine·D E Snider, W L Roper
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S B SnapperW R Jacobs
Sep 1, 1988·Journal of Bacteriology·B L Triggs-RaineP C Loewen
Mar 1, 1982·Biology of Reproduction·A C EndersP E Binkerd
Dec 1, 1954·American Review of Tuberculosis·G MIDDLEBROOK, S H DRESSLER

❮ Previous
Next ❯

Citations

Feb 1, 1996·Pediatric Pulmonology·L S Inselman
Apr 12, 2002·Chembiochem : a European Journal of Chemical Biology·M NguyenB Meunier
Mar 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Lal, S Lal
Sep 25, 2004·Medicinal Research Reviews·Rama P TripathiVinod K Tiwari
Nov 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Salfinger, G E Pfyffer
Nov 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C B Inderlied
Feb 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·V AusinaJ Roca
Aug 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·M Sritharan, V Sritharan
Sep 26, 2009·Journal of Molecular Modeling·Ashutosh Kumar, Mohammad Imran Siddiqi
Aug 23, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H J MarttilaH Soini
Aug 31, 2013·Current Infectious Disease Reports·Navaneetha Pandian Poorana Ganga Devi, Soumya Swaminathan
Aug 1, 1996·Molecular Aspects of Medicine·M J Colston
Jun 1, 1995·Molecular and Biochemical Parasitology·D M BrownP Upcroft
Apr 1, 1994·Diagnostic Microbiology and Infectious Disease·J M HuntD H Persing
Feb 1, 1993·Research in Microbiology·Y Zhang
Mar 1, 1994·Research in Microbiology·A E Suzuki, J M Inamine
Jan 1, 1996·Research in Microbiology·N Rastogi, J O Falkinham
Jan 1, 1996·Research in Microbiology·J C Sacchettini, J S Blanchard
Aug 1, 1994·International Journal of Antimicrobial Agents·V St Georgiev
Nov 1, 1993·Trends in Microbiology·G F Hatfull
Oct 1, 1994·Trends in Microbiology·S T Cole
Jul 1, 1996·Trends in Microbiology·C E Barry, K Mdluli
Nov 1, 1996·Trends in Microbiology·D M Collins
Nov 1, 1996·Trends in Microbiology·Y Zhang
Jan 7, 1998·Biochemical Pharmacology·C E Barry
Mar 12, 2003·Journal of Molecular Biology·Xavi CarpenaIgnacio Fita
Apr 27, 2000·Trends in Genetics : TIG·D M Faguy, W F Doolittle
Jul 26, 2002·Social Science & Medicine·Thomas KistemannFriederike Dangendorf
Mar 29, 2003·Diagnostic Microbiology and Infectious Disease·Maria J TorresJavier Aznar
Apr 3, 2001·International Journal of Antimicrobial Agents·S H Gillespie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.