The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample

Schizophrenia Research
Vanessa NieratschkerThomas G Schulze

Abstract

The aim of the present study was to investigate possible associations between schizophrenia and 13 SNP markers in COMT. No association was observed in 631 cases, 207 nuclear families, and 776 controls. A cognitive performance phenotype (Trail Marking Test) was available for a subgroup of the patients. No association was found between the 13 markers and this phenotype. Four clinically-defined subgroups (early age at onset, negative symptoms, family history of schizophrenia, and life-time major depressive episode) were also investigated. Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population.

References

Mar 1, 1996·The American Journal of Psychiatry·M F Green
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
May 3, 2002·Molecular Psychiatry·J A Badner, E S Gershon
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Jun 13, 2003·American Journal of Human Genetics·Nicholas J BrayMichael C O'Donovan
Jun 13, 2003·American Journal of Human Genetics·Cathryn M LewisTomas Helgason
Apr 21, 2004·Molecular Psychiatry·M A PalmatierK K Kidd
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Mar 31, 2005·The American Psychologist·R Walter Heinrichs
Apr 7, 2005·Human Heredity·Heiner FangerauThomas G Schulze
Apr 5, 2007·Nature Protocols·Christopher R Bowie, Philip D Harvey
Apr 7, 2007·Schizophrenia Bulletin·Hywel J WilliamsMichael C O'Donovan
Jul 10, 2007·Schizophrenia Bulletin·John A Gray, Bryan L Roth
Mar 15, 2008·Biological Psychiatry·Jennifer H BarnettMarcus R Munafò
Mar 31, 2009·Schizophrenia Research·Tomo OkochiNakao Iwata
May 1, 2009·Journal of the International Neuropsychological Society : JINS·I Sánchez-CubilloF Barceló

❮ Previous
Next ❯

Citations

Feb 11, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Victoria RisbroughXianjin Zhou
Dec 6, 2011·Brain Research Bulletin·A Veronica Witte, Agnes Flöel
Sep 17, 2015·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Alexandre A LochWagner F Gattaz
Aug 16, 2012·Translational Psychiatry·Y HeD Rujescu

❮ Previous
Next ❯

Related Concepts

Related Feeds

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.