PMID: 25792770Jan 1, 2007Paper

The catecholamine system in health and disease -Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
T Nagatsu

Abstract

Catecholamines [dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine); CAs] are neurotransmitters in the central and peripheral nervous systems as well as hormones in the endocrine system. CAs in the brain play a central role in versatile functions as slow-acting neurotransmitters functioning in synaptic neurotransmission, modulating the effects of fast-acting neurotransmitters such as glutamate and γ-aminobutyric acid (GABA). In this review, I focus on recent advances in the biochemistry and molecular biology of the CA system in humans in health and disease, especially in neuropsychiatric diseases such as Parkinson's disease (PD), in relation to the biosynthesis of CAs regulated by a pteridine-dependent monooxygenase, tyrosine 3-monooxygenase (tyrosine hydroxylase, TH) and its pteridine cofactor, tetrahydrobiopterin (BH4).

References

Mar 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·T NagatsuM Sano
Nov 30, 1992·Biochemical and Biophysical Research Communications·T NakanoT Nagatsu
Apr 15, 1992·Biochemical and Biophysical Research Communications·L LankiewiczA F Spatola
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Aug 30, 1991·Biochemical and Biophysical Research Communications·H IchinoseT Nagatsu
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Oct 1, 1973·Analytical Biochemistry·T NagatsuS Udenfriend
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Citations

Dec 16, 2016·Expert Opinion on Therapeutic Targets·Kai WaløenJan Haavik
Apr 28, 2009·Journal of Neural Transmission·A NakashimaA Ota
Dec 26, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hsuan ChungToshiro Matsui
Jul 12, 2018·Journal of Neural Transmission·Toshiharu NagatsuKazuto Kobayashi
Jan 19, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Marine P M LetertreIan D Wilson

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