The cation-uptake regulators AdcR and Fur are necessary for full virulence of Streptococcus suis

Veterinary Microbiology
Jesús ArandaJordi Barbé

Abstract

In streptococci, the pleiotropic regulators AdcR and Fur control the transport of, zinc and iron, respectively, which are essential components of many proteins. In this work, DeltaadcR, Deltafur, and DeltaadcR Deltafur mutants of Streptococcus suis, a serious pathogen in pigs and humans, were assayed in a mouse model to determine their involvement in the virulence of this bacterium. The results showed, for the first time, that the virulence of S. suis mutants carrying an inactivation of adcR, fur, or both genes is significantly attenuated compared to the wild-type parent strain. Furthermore, all mutants were found to be more sensitive to oxidative stress. Our data provide evidence that the adcR and fur genes play important roles in the oxidative stress response of S. suis as well as in the full virulence of this bacterium.

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Citations

Jul 16, 2013·Antonie van Leeuwenhoek·Gustavo Pelicioli RiboldiJeverson Frazzon
Apr 19, 2011·Nihon saikingaku zasshi. Japanese journal of bacteriology·Daisuke Takamatsu
Jan 12, 2013·FEMS Microbiology Letters·Maud FléchardAgnès Rosenau
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Nov 6, 2013·Antimicrobial Agents and Chemotherapy·Alejandro BeceiroGermán Bou
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Apr 5, 2018·Frontiers in Cellular and Infection Microbiology·Hua NiXiuzhen Pan
Oct 4, 2018·Frontiers in Cellular and Infection Microbiology·Haodan ZhuKongwang He
Aug 31, 2019·Emerging Microbes & Infections·Chengkun ZhengPingping Zhou

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