Jun 2, 2020

The CatWalk XT® is a valid tool for objective assessment of motor function in the acute phase after controlled cortical impact in mice

Behavioural Brain Research
Johannes WalterKlaus Zweckberger

Abstract

Despite multiple experimental models of traumatic brain injury (TBI) being available, objective assessment of gait and motor function in rodents remains difficult; therefore, we studied the value of the CatWalk XT® gait analysis as an observer independent, automated method for outcome assessment in one of the most frequently used preclinical TBI model, the controlled cortical impact (CCI), in mice. C57Bl/6 mice were subjected to either right parietal CCI or a sham procedure. Functional outcome was assessed using the CatWalk XT® (Version 10.6) as well as the hole board test at days one, three and seven after trauma induction. CCI led to diffuse, asymmetric and bilateral disturbances of both static and dynamic parameters in the CatWalk XT® gait analysis. The CatWalk XT® detected even minimal but statistically significant impairments that could not have been detected by clinical assessments. Impairments of static parameters were most pronounced within the first three days and diminished thereafter, while dynamic parameters were impaired until seven days after CCI. Fittingly, mice explored the hole board significantly less on day three trauma induction. The CatWalk XT® is a valid tool for objective assessment of motor function in t...Continue Reading

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Mentioned in this Paper

Bilateral
RB1CC1
Placebos
Cerebral Cortex
Detected (Finding)
Asymmetry
Rodent
Pre-Clinical Model
Gait
Medical Devices

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