The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference

CNS Neuroscience & Therapeutics
Yongmei SunShang-Chuan Yang

Abstract

The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine-induced CPP. Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory.

References

Aug 1, 1987·The Journal of Comparative Neurology·A J McDonald, T R Jackson
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·K A ZitoD van der Kooy
May 24, 2003·Neuroscience and Behavioral Physiology·V G Aleksandrov, K P Fedorova
Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Emmanuel ValjentJean-Antoine Girault
Sep 29, 2006·Journal of Neurophysiology·Alexander M BenisonDaniel S Barth
Jan 27, 2007·Science·Nasir H NaqviAntoine Bechara
Apr 22, 2008·Cerebral Cortex·Krista M RodgersDaniel S Barth
May 2, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Chia-Chi Liao, Chen-Tung Yen
Nov 7, 2008·Trends in Neurosciences·Nasir H Naqvi, Antoine Bechara
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan A HollanderPaul J Kenny
Mar 20, 2010·Biological Psychiatry·Benoit ForgetBernard Le Foll
Jun 1, 2010·Brain Structure & Function·Nasir H Naqvi, Antoine Bechara
Jun 1, 2010·Brain Structure & Function·Hugh Garavan
Aug 7, 2010·Science·Tiziana Sacco, Benedetto Sacchetti
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander M BenisonDaniel S Barth
Dec 20, 2011·Brain Research Bulletin·Simona Gardini, Annalena Venneri
Jan 11, 2012·Progress in Brain Research·Rudolf Nieuwenhuys
Feb 4, 2012·Science·Karen D ErscheEdward T Bullmore
Apr 27, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco ContrerasFernando Torrealba
May 28, 2015·Pharmacology, Biochemistry, and Behavior·YongMei SunJianHong Wang
Jun 13, 2015·Trends in Cognitive Sciences·Vita DroutmanAntoine Bechara
Aug 10, 2015·Pharmacology, Biochemistry, and Behavior·Rebecca L PomfreyAnthony L Riley
Aug 22, 2015·Biological Psychiatry·Yan ZhangJie Shi

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Citations

Jul 18, 2019·Frontiers in Pharmacology·Christine IbrahimBernard Le Foll
Apr 9, 2021·Peptides·Richard J Bodnar
Jun 12, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hailei YuChunling Ma

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