The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus.

Neuroscience
K A Takahashi, P E Castillo

Abstract

Cannabinoids have profound effects on synaptic function and behavior. Of the two cloned cannabinoid receptors, cannabinoid receptor 1 (CB1) is widely distributed in the CNS and accounts for most of the neurological effects of cannabinoids, while cannabinoid receptor 2 (CB2) expression in the CNS is very limited. The presence of additional receptors [i.e. cannabinoid receptor 3 (CB3)] is suggested by growing evidence of cannabinoid effects that are not mediated by CB1 or CB2. The most direct functional evidence for a CB3 comes from a study in hippocampus where deletion of CB1 was shown to have no effect on cannabinoid-mediated suppression of the excitatory synapse between Schaffer collateral/commissural fibers and CA1 pyramidal cells [Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Neuroscience 106:1-4]. In contrast, we report here that in extracellular field recordings, the cannabinoid agonist WIN 55,212-2 (5 microM) had no effect on Schaffer collateral/commissural fiber-CA1 pyramidal cell (Sch-CA1) synaptic transmission in slices from two independently made cannabinoid receptor 1-/- lines [Zimmer et al 1999 and Ledent et al 1999] while strongly suppressing Sch...Continue Reading

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Citations

Jul 18, 2009·European Archives of Psychiatry and Clinical Neuroscience·Deepak Cyril D'SouzaMohini Ranganathan
Aug 4, 2009·Nature Neuroscience·Emma PuighermanalAndrés Ozaita
Nov 23, 2006·Nature Neuroscience·David RobbeGyörgy Buzsaki
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hiroki YasudaTadaharu Tsumoto
Mar 8, 2008·Learning & Memory·Shahnaz Christina AzadGerhard Rammes
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Dec 17, 2010·Journal of Neurophysiology·Sameera Dasari, Allan T Gulledge
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·István KatonaTamás F Freund
May 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chiayu Q ChiuPablo E Castillo
Aug 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas J YountsPablo E Castillo
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander F HoffmanCarl R Lupica
Sep 29, 2009·European Journal of Pharmacology·André SerpaAna M Sebastião
Jul 8, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sudhir N UmatheNishant S Jain
Mar 14, 2008·Molecular and Cellular Endocrinology·Ken Mackie
Jun 15, 2007·Neurobiology of Aging·Yannick MarchalantGary L Wenk
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