The Ccr4-Not complex is a key regulator of eukaryotic gene expression

Wiley Interdisciplinary Reviews. RNA
Martine A Collart

Abstract

The Ccr4-Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the nucleus to their degradation in the cytoplasm. In the nucleus it influences the post-translational modifications of the chromatin template that has to be remodeled for transcription, it is present at sites of transcription and associates with transcription factors as well as with the elongating polymerase, it interacts with the factors that prepare the new transcript for export to the cytoplasm and finally is important for nuclear quality control and influences mRNA export. In the cytoplasm it is present in polysomes where mRNAs are translated and in RNA granules where mRNAs will be redirected upon inhibition of translation. It influences mRNA translatability, and is needed during translation, on one hand for co-translational protein interactions and on the other hand to preserve translation that stalls. It is one of the relevant players during co-translational quality control. It also interacts with factors that will repress translation or induce mRNA decapping when recruited to the translating template. Finally, Ccr4-Not carries deadenylating enzym...Continue Reading

References

Jan 19, 2000·Nucleic Acids Research·T K AlbertH T Timmers
Mar 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Wind, D Reines
Oct 12, 2000·Journal of Molecular Biology·L MailletM A Collart
Sep 7, 2002·Molecular and Cellular Biology·Cécile DeluenMartine A Collart
Nov 6, 2002·Molecular and Cellular Biology·Domenico LibriTorben Heick Jensen
Apr 1, 2003·Molecular and Cellular Biology·Mark J SwansonAlan G Hinnebusch
Jul 29, 2003·Progress in Nucleic Acid Research and Molecular Biology·Clyde L Denis, Junji Chen
Jan 7, 2004·The Journal of Biological Chemistry·Carin G M ZwartjesH T Marc Timmers
Jun 16, 2004·Progress in Nucleic Acid Research and Molecular Biology·Martine A Collart, H Th Marc Timmers
Sep 24, 2005·Cell·Jeff Coller, Roy Parker
Dec 17, 2005·Genes & Development·Rona LotanMordechai Choder
Jun 17, 2006·The EMBO Journal·G Sebastiaan WinklerH Th Marc Timmers
Jun 24, 2006·The Journal of Biological Chemistry·Mandy JeskeElmar Wahle
Aug 24, 2006·The Journal of Biological Chemistry·Olesya PanasenkoMartine A Collart
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·R Nicholas LaribeeBrian D Strahl
Mar 29, 2007·The Journal of Biological Chemistry·Brad A HookMarvin Wickens
Mar 30, 2007·Nucleic Acids Research·Klaas W MulderH Th Marc Timmers
Apr 13, 2007·Molecular Biology of the Cell·Daniela Teixeira, Roy Parker
May 22, 2008·Genetics·Weimin PengSiavash K Kurdistani
Feb 11, 2009·The Journal of Biological Chemistry·Lyudmila N DimitrovaToshifumi Inada
Apr 7, 2009·Genes & Development·Douglas P MersmanScott D Briggs
Aug 25, 2009·Nature·Wenqian HuJeff Coller
Sep 12, 2009·Journal of Cellular Physiology·G Sebastiaan Winkler
Jul 17, 2010·The Journal of Biological Chemistry·Amy CookeMarvin Wickens
Sep 14, 2010·Nature·Mario H Bengtson, Claudio A P Joazeiro
Feb 16, 2011·Molecular and Cellular Biology·Olesya O Panasenko, Martine A Collart
Mar 17, 2011·Genes & Development·Jennifer A KrukJoseph C Reese

❮ Previous
Next ❯

Citations

Jun 28, 2016·Nucleic Acids Research·Anastasiia KamenskaNancy Standart
Jun 14, 2016·Journal of Cardiovascular Development and Disease·Manfred Frasch
Aug 10, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marta UklejaJorge Cuellar
Aug 23, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Zoltan Villanyi, Martine A Collart
Nov 5, 2016·Biochimica Et Biophysica Acta·Anna ŁabnoAndrzej Dziembowski
Oct 18, 2016·Trends in Biochemical Sciences·Toshifumi Inada
May 7, 2016·Genes & Development·Rene GeisslerAndrew Grimson
Apr 14, 2017·Genome Research·Cornelia BrönnerMario Halic
Oct 27, 2017·Nucleic Acids Research·Adriana MenaJosé E Pérez-Ortín
Oct 20, 2017·Disease Models & Mechanisms·Philipp FollwacznyMichael A Kiebler
Jun 21, 2018·Memórias do Instituto Oswaldo Cruz·Jimena Ferreira da CostaFabíola Barbieri Holetz
Aug 26, 2017·ELife·Fabrizio SimonettiMathieu Rougemaille
Oct 4, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Nguyen Thi Minh VietKenji Irie
Jan 30, 2019·Genes & Development·Csilla KeskenyElisa Izaurralde
Feb 16, 2019·American Journal of Medical Genetics. Part a·Tomoko UeharaKenjiro Kosaki
May 23, 2019·Molecular Plant Pathology·Hugo Massayoshi ShimoCelso Eduardo Benedetti
Jun 11, 2019·Nucleic Acids Research·Hedda A MeijerMartin Bushell
May 1, 2019·Molecular and Cellular Biology·Wi S LaiPerry J Blackshear
Aug 9, 2019·Nucleic Acids Research·Victoria BegleySebastián Chávez
Sep 19, 2019·Molecular Microbiology·Sandra Bennink, Gabriele Pradel
Dec 28, 2019·Plant & Cell Physiology·Kazuki MotomuraYukako Chiba
Oct 11, 2019·Nucleic Acids Research·Martine A Collart, Benjamin Weiss
Oct 16, 2019·Molecular and Cellular Biology·Shun HosoyamadaTakehiko Kobayashi
May 6, 2020·The Plant Journal : for Cell and Molecular Biology·Patrícia A PereiraJörg D Becker
May 31, 2020·Disease Models & Mechanisms·Lisa ElménRolf Bodmer
Aug 14, 2020·Wiley Interdisciplinary Reviews. RNA·Yong-Bin Yan
Jun 11, 2020·The Journal of Biological Chemistry·Jonathan FischerMordechai Choder
Oct 2, 2020·Physiological Reviews·Rico SchieweckMichael A Kiebler
Jul 19, 2017·Annual Review of Cell and Developmental Biology·Claudio A P Joazeiro
Mar 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Brigitte GrimaFrançois Rouyer
May 29, 2020·Nucleic Acids Research·Alex G JohnsonJoseph D Puglisi
Jan 20, 2018·Nature Immunology·Martin Turner, Manuel D Díaz-Muñoz
Dec 7, 2018·Nature Structural & Molecular Biology·Jeffrey S MugridgeJohn D Gross
Jan 30, 2019·Nature Structural & Molecular Biology·Xiao-Min Liu, Shu-Bing Qian

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
acetylates
ubiquitination
acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wiley Interdisciplinary Reviews. RNA
Susanne Huch, Tracy Nissan
Wiley Interdisciplinary Reviews. RNA
Clément Chapat, Laura Corbo
Wiley Interdisciplinary Reviews. RNA
Jeff Wilusz
© 2021 Meta ULC. All rights reserved