The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability

Journal of Affective Disorders
Filip VentorpPatrik Brundin

Abstract

The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell adhesion molecule that binds to HA in the ECM and is present on astrocytes, microglia and certain neurons. Cell adhesion molecules have been reported to be involved in anxiety and mood disorders. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in brain GWAS studies as a possible risk gene for suicidal behavior. We measured the CSF levels of HA and the soluble CD44 (sCD44) in suicide attempters (n=94) and in healthy controls (n=45) using ELISA and electrochemiluminescence assays. We also investigated other proteins known to interact with CD44, such as osteopontin and the matrix metalloproteinases MMP1, MMP3 and MMP9. The suicide attempters had higher CSF levels of HA (p=.003) and MMP9 (p=.004). The CSF levels of HA correlated with BBB-permeability (rho=0.410, p<.001) and MMP9 correlated with sCD44 levels (rho=0.260, p=.005). Other relevant biological contributors to suicidal behavior is not addressed in parallel to the specific role of CD44-HA signaling. The gender distribution of the patients from whom CSF was analyzed was u...Continue Reading

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References

Jan 1, 1978·Acta Psychiatrica Scandinavica. Supplementum·M AsbergG Sedvall
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jun 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L Träskman-BendzR Ohman
Oct 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·A Engström-LaurentT C Laurent
May 1, 1973·Archives of General Psychiatry·C I Wold, R E Litman
Sep 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·P TyrerD V Cicchetti
Aug 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L Bayard-BurfieldL Träskman-Bendz
Sep 1, 1996·Acta Neurologica Scandinavica·U B LaurentK Lilja
Nov 5, 1997·The Psychiatric Clinics of North America·E K Mościcki
Mar 1, 2000·Molecular Pathology : MP·S GoodisonD Tarin
Jul 7, 2000·Journal of Consulting and Clinical Psychology·G K BrownJ R Grisham
Aug 6, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·J BienvenuJ P Revillard
Apr 28, 2001·Trends in Molecular Medicine·E Puré, C A Cuff
May 31, 2001·The Journal of Cell Biology·M KajitaM Seiki
Aug 31, 2002·Glia·Gary A Rosenberg
Nov 20, 2002·Journal of Neurochemistry·Xinkang WangGiora Z Feuerstein
Jul 29, 2003·Psychosomatic Medicine·Laura RedwineMichael Irwin
Nov 20, 2004·Nature Reviews. Neuroscience·Carmen Sandi
Jul 5, 2007·The International Journal of Neuropsychopharmacology·Andreas ThalmeierDan Rujescu
May 6, 2009·Fortschritte der Neurologie-Psychiatrie·H HimmerichT Pollmächer
Oct 22, 2009·The Journal of Comparative Neurology·Isaias GlezerSerge Rivest
Nov 26, 2009·Cardiovascular Psychiatry and Neurology·Hadar ShalevAlon Friedman
Oct 15, 2010·Nature Reviews. Neuroscience·Alexander DityatevPeter Sonderegger
Oct 19, 2010·Brain, Behavior, and Immunity·Shorena JanelidzeLena Brundin
Jan 5, 2011·Acta Psychiatrica Scandinavica·D LindqvistL Brundin
Jan 21, 2011·Physiological Reviews·Dianhua JiangPaul W Noble
Mar 3, 2011·The FEBS Journal·Suniti MisraShibnath Ghatak
Jul 2, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Daniel SoueryJulien Mendlewicz
Sep 24, 2011·Stress : the International Journal on the Biology of Stress·Reto Bisaz, Carmen Sandi
Nov 8, 2011·Drug Discovery Today. Disease Models·Herbert H Lipowsky
Dec 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Claudia DitzenChristoph W Turck
Dec 24, 2011·Current Alzheimer Research·Henrietta M NielsenMalin Wennström

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Citations

May 30, 2016·Colloids and Surfaces. B, Biointerfaces·Ya LiuXi-Guang Chen
Sep 28, 2016·Current Psychiatry Reports·Daniel Almeida, Gustavo Turecki
Jul 12, 2017·Molecular Psychiatry·P-E LutzG Turecki
Mar 29, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Abraham J Al-AhmadEric V Shusta
Jun 28, 2019·International Journal of Molecular Sciences·Emily F GoodallStephen B Wharton
Jul 6, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lena BrundinKeerthi Thirtamara Rajamani

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