PMID: 8613887Apr 1, 1996Paper

The CD4/CD8 ratio in the blood does not reflect the response of this index in secondary lymphoid organs of weanling mice in models of protein-energy malnutrition known to depress thymus-dependent immunity

The Journal of Nutrition
W H Lee, Bill Woodward

Abstract

A low ratio of cellular numbers within CD4+ (helper/inducer) relative to CD8+ (suppressor/cytotoxic) thymic lymphocyte subsets (low CD4/CD8 ratio) is widely accepted as fundamental to the depression in thymus-dependent immunocompetence associated with wasting protein-energy malnutrition (PEM). The objective of this investigation, therefore was to determine the CD4/CD8 ratio in peripheral lymphoid compartments of diverse murine models of protein-energy malnutrition which produce systemic wasting (loss of approximately 1.8% of initial body weight per day), lymphoid involution and (as shown in many previous studies) depression in thymus-dependent immunocompetence. In the first of two experiments, male and female weanling mice of disparate inbred strains, CBA/J and C57BL/6J, were allocated to a zero-time control group (23- and 19-d-old, respectively), or to groups fed for 14 d as follows: ad libitum intake of a complete purified diet (19% crude protein, 17 kJ/g gross energy), restricted intake of the complete diet, or ad libitum intake of an isocaloric low protein diet (0.6% crude protein). In a supplementary experiment, (0.6% crude protein). In a supplementary experiment, male and female C57BL/6J weanling mice were fed the complet...Continue Reading

Citations

Mar 11, 2017·Molecular and Cellular Biochemistry·Nevena Arsenović-RaninGordana Leposavić
Jan 1, 1997·European Archives of Psychiatry and Clinical Neuroscience·M MaesS Scharpé
Mar 17, 2011·Biological Trace Element Research·Yuanxin DengXiaodong Liu
May 22, 2013·The Proceedings of the Nutrition Society·Philip C Calder
Mar 3, 1998·Nutrition Reviews·B Woodward
Nov 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L M Hillyer, Bill Woodward
Apr 13, 2021·International Journal of Food Sciences and Nutrition·Åsa HåkanssonBengt Jeppsson

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