PMID: 9552412Jan 1, 1997Paper

The cdc18 protein initiates DNA replication in fission yeast

Progress in Cell Cycle Research
H Nishitani, P Nurse

Abstract

Recent work has demonstrated that cdc18p plays a crucial role in regulating the onset of S phase in fission yeast. cdc18p is a major product of START specific transcription and associates with ORC and MCM proteins which are required for the initiation of DNA replication. High expression of cdc18p induces continuing DNA synthesis and is thought to drive the assembly of initiation complexes. In addition to its role in bringing about DNA replication, cdc18p participates in the cell cycle checkpoint control linking S phase to START and mitosis. We propose that cdc18p is central to the molecular mechanism co-ordinating S phase and M phase in concert with changes in activity of the master cell cycle regulator, the cdc2 protein kinase.

Citations

Feb 6, 2002·The Journal of Biological Chemistry·Naoko TakahashiTohru Mizushima
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·M WeinreichB Stillman
Apr 25, 2000·Molecular and Cellular Biology·K TanakaH Okayama
Jul 28, 2004·Molecular Reproduction and Development·Jean-Marc LemaîtreMarcel Méchali

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