PMID: 9552362Jan 1, 1995Paper

The Cdc28 inhibitor p40SIC1

Progress in Cell Cycle Research
M D MendenhallT T Nugroho

Abstract

Sic1 inhibits the activity of Cdc28.Clb5 complexes in late G1, creating a delay between cell cycle commitment and S phase initiation. The ultimate purpose of this delay is unknown but loss of Sic1 activity negatively affects genomic stability and cellular viability. Sic1 levels are controlled by periodic changes in transcription rates and protein stability. The latter control is mediated through the Cdc34 ubiquitin transferase and, possibly, Cdc28.Cln activity. Possible roles of Sic1 in the G1/S and the M/G1 transitions are discussed.

Citations

Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Taku ChibazakuraJames M Roberts
Feb 4, 2011·Journal of the Royal Society, Interface·P K VinodBela Novak
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·M WeinreichB Stillman
Dec 6, 2001·Nature·J E Ferrell
Sep 14, 2007·Molecular Microbiology·Dongqing HuangBrenda Andrews
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·M D Mendenhall, A E Hodge
Aug 4, 2007·Biochemical and Biophysical Research Communications·Ritu PathakMichael Polymenis

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