PMID: 11331529May 2, 2001Paper

The cell adhesion molecule BEN defines a prosensory patch in the developing avian otocyst

The Journal of Comparative Neurology
R J GoodyearG P Richardson

Abstract

The distribution of the cell adhesion molecule BEN in the developing chick inner ear is described. BEN is first detected in the otic placode at stage 11. As the placode begins to invaginate, BEN becomes concentrated in a ventromedial region extending from the anterior to the posterior end of the otic pit. BEN expression levels increase in this region as the pit closes to form the otocyst, and distinct boundaries become defined along the dorsal and ventral edges of the ventromedial band of BEN expression. BEN expression also becomes concentrated dorsally within the otic epithelium as the pit closes and is observed in the condensing otic ganglion. By stage 22, the ventromedial band of BEN expression splits into two distinct regions, a small caudal patch within which the posterior crista will develop, and a larger anterior patch. By stage 26, this larger anterior patch of cells expressing BEN becomes subdivided into five separate areas corresponding to the regions within which the anterior crista, the lateral crista, the utricle, the saccule, and both the basilar papilla and lagenar macula form. Hair cells only develop within these regions defined by BEN distribution. The data suggest that the ventromedial patch of BEN expression ...Continue Reading

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Citations

Sep 12, 2006·Development, Growth & Differentiation·Hiromitsu MiyazakiJun-ichi Funahashi
Aug 19, 2005·BMC Developmental Biology·Huawei LiStefan Heller
Sep 19, 2012·The Journal of Comparative Neurology·Luis Óscar Sánchez-GuardadoMatías Hidalgo-Sánchez
Dec 21, 2012·Development, Growth & Differentiation·Joana NevesFernando Giraldez
Feb 21, 2004·Developmental Biology·Berta AlsinaFernando Giraldez
Jul 29, 2004·The Journal of Comparative Neurology·Huawei LiStefan Heller
Apr 30, 2003·The Journal of Comparative Neurology·Jennifer S StoneStanislav Tomarev
Apr 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexander DaviesJulian Lewis
Sep 27, 2002·British Medical Bulletin·Jane BryantGuy P Richardson

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