The cell biology of synaptic inhibition in health and disease.

Current Opinion in Neurobiology
Katharine R Smith, Josef T Kittler

Abstract

Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA(A)Rs at inhibitory synapses play a key role in the dynamic regulation of inhibitory synaptic efficacy and plasticity. The regulatory pathways essential for the fine-tuning of synaptic inhibition have also emerged as key sites of vulnerability during pathological changes in cell excitability in disease states.

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Citations

Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kai Y FanMark D Bevan
Mar 29, 2013·Autonomic Neuroscience : Basic & Clinical·Raj K Goyal, Arun Chaudhury
Apr 27, 2017·Journal of Veterinary Emergency and Critical Care·Susan Blades Golubovic, John H Rossmeisl
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Apr 25, 2014·Current Neurology and Neuroscience Reports·Sara HockerW David Freeman
May 13, 2011·Developmental Neurobiology·Giovanni EspositoPatrik Verstreken
Aug 13, 2013·The Journal of Biological Chemistry·Severine ChaumontMaurice Garret
Jul 10, 2019·The European Journal of Neuroscience·Katja SaldeitisEike Budinger
Nov 15, 2019·Cytoskeleton·Keertana VenkateshSandhya P Koushika
Sep 26, 2015·Current Neurology and Neuroscience Reports·Mauricio Ruiz Cuero, Panayiotis N Varelas
Jul 1, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Toshifumi TomodaTakeshi Sakurai
Sep 29, 2018·Histochemistry and Cell Biology·Femke L GroenewegJoachim Kirsch
Jul 12, 2019·Frontiers in Molecular Neuroscience·Vladimir Khayenko, Hans Michael Maric
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Jun 3, 2021·International Journal of Molecular Sciences·François Maingret, Laurent Groc
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Dipen RajgorKatharine R Smith

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