The cell boundary theorem: a simple law of the control of cytosolic calcium concentration.

The Journal of Physiological Sciences : JPS
Eduardo Ríos

Abstract

Many molecular biological interventions in current use, as well as inheritable disease conditions, modify the intracellular endowment of molecules that bind Ca(2+) or channels and pumps that transfer it to and from intracellular storage organelles. A simple law, named the "cell boundary theorem," states that intracellular alterations cannot directly result in changes in the cytosolic concentration, [Ca(2+)](i), in a true resting state. A demonstration of the validity of this theorem is provided. Several examples are then discussed of interventions or diseases that increase leak of Ca(2+) from storage organelles and result in greater resting [Ca(2+)](i). According to the theorem, the increase in [Ca(2+)](i) cannot be a direct consequence of the greater leak. Its primary cause must be a change of the fluxes at the level of the plasmalemma, caused in turn by the increase in leak through some sort of "store-operated Ca(2+) entry." While the law is discussed in terms of Ca(2+) homeostasis, it applies to any solute that may be transported by the plasma membrane.

References

Feb 1, 1986·Cell Calcium·J W Putney
Nov 19, 2004·American Journal of Physiology. Cell Physiology·Claudio F PerezPaul D Allen
Feb 25, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marco DaineseFeliciano Protasi

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Citations

Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·José Miguel EltitJosé R Lopez
Aug 17, 2010·The Journal of Biological Chemistry·Eduardo Ríos
Nov 20, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José M EltitJosé R Lopez
Dec 25, 2012·The Journal of Physiological Sciences : JPS·David Friel
Dec 25, 2012·The Journal of Physiological Sciences : JPS·Eduardo Ríos
Dec 23, 2015·Cellular Signalling·Alexandre BuduMarcos L Gazarini
Dec 4, 2014·Cell Calcium·Roberto Docampo, Guozhong Huang
May 27, 2015·The Journal of General Physiology·Eduardo RíosSheila Riazi
Dec 12, 2012·Journal of Molecular and Cellular Cardiology·David EisnerAndrew Trafford
May 18, 2010·Biochimica Et Biophysica Acta·Laura ContrerasTullio Pozzan
Jun 16, 2017·The Journal of Physiology·Rajiv SankaranarayananDavid A Eisner
Dec 17, 2017·The Journal of General Physiology·Alberto ZulloWerner Melzer
Oct 27, 2017·The Journal of Physiology·David A Eisner
Jul 8, 2017·Circulation Research·David A EisnerAndrew W Trafford
Jan 31, 2020·Circulation Research·David A EisnerDavid C Hutchings
Jan 13, 2019·The Journal of General Physiology·Niklas IvarssonHåkan Westerblad
Jun 21, 2019·Current Medicinal Chemistry·Alejandra Cecilia SchoijetGuillermo Daniel Alonso
May 6, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer M RutkowskyJon J Ramsey
Aug 15, 2019·American Journal of Physiology. Cell Physiology·Katja K PedersenKristian Overgaard
Dec 15, 2020·The Journal of General Physiology·Aldo Meizoso-Huesca, Bradley S Launikonis
Aug 31, 2019·JACC. Basic to Translational Science·Sabine LotteauSarah Calaghan
Nov 19, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryo TakagiYutaka Kano
Feb 28, 2021·Pflügers Archiv : European journal of physiology·Paul RosenbergChaojian Wang

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