The Cell Cycle Checkpoint Regulator ATR Is Required for Internal Aluminum Toxicity-Mediated Root Growth Inhibition inArabidopsis

Frontiers in Plant Science
Yang ZhangChao-Feng Huang

Abstract

Aluminum (Al) can target multiple sites of root cells for toxicity, including the cell wall, the plasma membrane and symplastic components. Previous work revealed that the cell cycle checkpoint regulator (ATR) Ataxia Telangiectasia-mutated and Rad3-related is required for Al toxicity-induced root growth inhibition inals3and that the symplastic component DNA is an important target site of Al for the toxicity. However, whether monitoring DNA integrity through ATR-regulated pathway is required for Al-induced root growth inhibition in other Al-sensitive mutants remains unknown. In this study, we demonstrated that theatrmutation could also rescue the Al hypersensitivity and Al-induced cell cycle arrest instar1, which supports the hypothesis that ALS3 and STAR1 function together to be involved in the detoxification of Al inArabidopsis. However, mutation ofATRcould not rescue the Al-sensitive phenotype ofalmt1orstop1, both of which are defective in external detoxification mechanisms of Al. We further showed that the Al hypersensitivity and Al-induced quiescent center (QC) differentiation inals1could also be rescued by theatrmutation. Therefore, our results suggest that ATR-regulated pathway is involved in the modulation of internal Al...Continue Reading

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Citations

May 16, 2019·Journal of Zhejiang University. Science. B·Jian-Li YangShao-Jian Zheng
Nov 7, 2019·Frontiers in Plant Science·Miriam Szurman-ZubrzyckaIwona Szarejko
Nov 18, 2020·International Journal of Molecular Sciences·Joanna JaskowiakIwona Szarejko

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Methods Mentioned

BETA
genotyping

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ImageJ

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