The cell death regulator GRIM-19 is involved in HIV-1 induced T-cell apoptosis

Apoptosis : an International Journal on Programmed Cell Death
Manoj Kumar TripathyDebashis Mitra

Abstract

One of the hallmarks of Human Immunodeficiency Virus-1 (HIV-1) infection is progressive depletion of the infected and bystander CD4+ T-cells by apoptosis. Different mitochondrial proteins have been implicated in this apoptotic process; however, the role of different subunits of mitochondrial oxidative phosphorylation (OXPHOS) complexes in apoptosis is not clearly understood. Some of the OXPHOS complex subunits seem to perform other functions in addition to their primary role in energy generating process. GRIM-19 (gene associated with retinoid-interferon-induced-mortality-19), a subunit of mitochondrial complex-I was previously implicated in Interferon-β and retionoic acid induced apoptosis in many tumor cells. In this study we report, using differential gene expression analysis, that GRIM-19 is up-regulated in HIV-1 infected apoptotic T-cells. A temporal up regulation of this subunit was observed in different HIV-1 infected T-cell lines and human PBMC and the extent of increase correlated to increasing apoptosis and virus production. Moreover, silencing GRIM-19 in HIV-1 infected cells reduced apoptosis, indicating its involvement in HIV-1 induced T-cell death.

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Sep 23, 2009·Apoptosis : an International Journal on Programmed Cell Death·Manoj Kumar Tripathy, Debashis Mitra

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Citations

Mar 7, 2012·Apoptosis : an International Journal on Programmed Cell Death·Fan DingLi-Ming Xiong
May 11, 2012·Medical Oncology·Xiao-Yun FanRong-Yu Liu
Dec 26, 2015·Fish & Shellfish Immunology·Ting PengYuan Liu
May 5, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ying ZhouWeihua Xiao
Mar 27, 2013·Innate Immunity·Peeraya EkchariyawatPongsak Utaisincharoen

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis