PMID: 6165274Jan 1, 1980Paper

The cell growth inhibitory and antiviral effects of interferon in cloned transformed mouse cells

Annals of the New York Academy of Sciences
L BoreckýJ Capková

Abstract

Eight clones and two subclones of SV40- and seven clones and one subclone of 20-methylcholanthrene-transformed C3H mouse embryonic fibroblasts were compared in tests for sensitivity to the antiviral and cell-growth inhibitory activities of a partially purified mouse L-cell interferon. While the sensitivity of clones and subclones to the antiviral activity of interferon was comparable to that of parent lines, the cell-growth inhibitory activity of interferon in the SV40 clones showed more than 100-fold variation and the methylcholanthrene-transformed cells could be divided into two groups in this respect. No correlation of sensitivity to the cell-growth inhibitory effect of interferon with the chromosome number, interferon-producing capacity or tumorigenicity of the clones could be detected. However, the cells of the interferon-sensitive clones No. 36 of the methylcholanthrene-transformed line were destroyed by macrophages at higher percentage binding of 125I-labeled soybean lectin. These results suggest that (1) the cell-growth inhibitory effect of interferon might be mediated by a specific type of receptors, and (2) N-acetyl-galactosamine present on the surface of interferon-resistant cells in a higher concentration than on in...Continue Reading

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Citations

Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I Gresser
Sep 1, 1987·International Journal of Cell Cloning·J TsukadaS Eto

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