The cells and peripheral representation of sodium taste in mice.

Nature
Jayaram ChandrashekarCharles S Zuker

Abstract

Salt taste in mammals can trigger two divergent behavioural responses. In general, concentrated saline solutions elicit robust behavioural aversion, whereas low concentrations of NaCl are typically attractive, particularly after sodium depletion. Notably, the attractive salt pathway is selectively responsive to sodium and inhibited by amiloride, whereas the aversive one functions as a non-selective detector for a wide range of salts. Because amiloride is a potent inhibitor of the epithelial sodium channel (ENaC), ENaC has been proposed to function as a component of the salt-taste-receptor system. Previously, we showed that four of the five basic taste qualities-sweet, sour, bitter and umami-are mediated by separate taste-receptor cells (TRCs) each tuned to a single taste modality, and wired to elicit stereotypical behavioural responses. Here we show that sodium sensing is also mediated by a dedicated population of TRCs. These taste cells express the epithelial sodium channel ENaC, and mediate behavioural attraction to NaCl. We genetically engineered mice lacking ENaCalpha in TRCs, and produced animals exhibiting a complete loss of salt attraction and sodium taste responses. Together, these studies substantiate independent cellu...Continue Reading

References

Jun 1, 1991·Journal of Neurophysiology·M E Frank
May 1, 1990·The American Journal of Clinical Nutrition·G K BeauchampK Engelman
Apr 9, 1990·Brain Research·T P Hettinger, M E Frank
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S S SchiffmanF W Maes
Dec 1, 1994·Physiology & Behavior·G Hellekant, Y Ninomiya
Apr 1, 1996·The Journal of General Physiology·R E Doolin, T A Gilbertson
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y Ninomiya
Dec 19, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O KretzB Lindemann
Dec 23, 1998·Neuroscience and Biobehavioral Reviews·B P Halpern
Sep 15, 2001·Nature·B Lindemann
Feb 22, 2002·Genesis : the Journal of Genetics and Development·Edith HummlerFriedrich Beermann
Mar 15, 2002·Nature·Greg NelsonCharles S Zuker
Nov 26, 2003·Cell·Grace Q ZhaoCharles S Zuker
Mar 11, 2005·Nature·Ken L MuellerNicholas J P Ryba
Apr 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shachar Eylam, Alan C Spector
Aug 25, 2006·Nature·Angela L HuangCharles S Zuker
Jan 4, 2008·BMC Neuroscience·Aurelie VandenbeuchSue C Kinnamon
Jan 27, 2009·Neuroscience·R YoshidaY Ninomiya
Oct 17, 2009·Science·Jayaram ChandrashekarCharles S Zuker
Oct 20, 2009·Cell·David A YarmolinskyNicholas J P Ryba
Nov 26, 2009·BMJ : British Medical Journal·Pasquale StrazzulloFrancesco P Cappuccio

❮ Previous
Next ❯

Citations

Aug 5, 2010·Pflügers Archiv : European journal of physiology·Martin TresguerresLonny R Levin
Jun 1, 2010·Brain Structure & Function·Dana M Small
May 17, 2012·Amino Acids·Misako KawaiYuzo Ninomiya
Aug 7, 2012·Amino Acids·Ana San Gabriel, Hisayuki Uneyama
Nov 28, 2013·Pharmacology & Therapeutics·Simon R FosterWalter G Thomas
Nov 3, 2011·Journal of Agricultural and Food Chemistry·Alexander SchindlerThomas Hofmann
Dec 12, 2012·Journal of Agricultural and Food Chemistry·Susann KohlWolfgang Meyerhof
Feb 15, 2013·Nature·Yuki OkaCharles S Zuker
May 17, 2011·Nature Neuroscience·Ichiro MatsumotoKeiko Abe
Sep 10, 2013·Nature Neuroscience·Sarah G Leinwand, Sreekanth H Chalasani
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Toshihiro KimuraDaniela Rotin
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rui B ChangEmily R Liman
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephan Frings
Apr 22, 2010·The Journal of Biological Chemistry·Hitoshi KawaguchiMakoto Tominaga
May 19, 2010·Chemical Senses·Michael G Tordoff
Jul 8, 2010·Chemical Senses·Theodore M NelsonSusan L Sullivan
Jul 12, 2011·Chemical Senses·Glen J GoldenAlexander A Bachmanov
Feb 2, 2012·Chemical Senses·Yutaka Ishiwatari, Alexander A Bachmanov
Sep 15, 2012·Chemical Senses·Antti KnaapilaDanielle R Reed
Sep 27, 2012·Chemical Senses·Anja VoigtWolfgang Meyerhof
May 29, 2013·Clinical and Experimental Pharmacology & Physiology·Cara J Büsst
Sep 3, 2011·Acta Physiologica·K IwatsukiK Torii
Jan 4, 2013·Nutrition Reviews·John A DeSimoneGuy H Johnson
Sep 3, 2011·Science·Xiaoke ChenCharles S Zuker
Jun 15, 2013·Science·Yali V ZhangCraig Montell
Jan 27, 2012·American Journal of Physiology. Cell Physiology·Yawar J QadriCatherine M Fuller
Nov 26, 2010·American Journal of Physiology. Cell Physiology·Arian F Baquero, Timothy A Gilbertson
Oct 12, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kimberly R SmithAlan C Spector
Jun 18, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ginger BlondeAlan C Spector
Aug 17, 2012·Journal of Neurophysiology·Joseph M Breza, Robert J Contreras
Jun 4, 2010·Journal of Neurophysiology·Yoshihiro MurataYuzo Ninomiya
Dec 30, 2011·Journal of Neurophysiology·Joseph M Breza, Robert J Contreras
Mar 16, 2011·Digestion·Gary K Beauchamp, Julie A Mennella
Nov 5, 2010·Biological & Pharmaceutical Bulletin·Mayu NikiYuzo Ninomiya
Aug 12, 2010·PloS One·Michael S SinclairNirupa Chaudhari
Jun 1, 2011·PloS One·Nao HorioYuzo Ninomiya

❮ Previous
Next ❯

Software Mentioned

Adobe Photoshop

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.