The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

Neuron
John C SilbereisNenad Sestan

Abstract

The human CNS follows a pattern of development typical of all mammals, but certain neurodevelopmental features are highly derived. Building the human CNS requires the precise orchestration and coordination of myriad molecular and cellular processes across a staggering array of cell types and over a long period of time. Dysregulation of these processes affects the structure and function of the CNS and can lead to neurological or psychiatric disorders. Recent technological advances and increased focus on human neurodevelopment have enabled a more comprehensive characterization of the human CNS and its development in both health and disease. The aim of this review is to highlight recent advancements in our understanding of the molecular and cellular landscapes of the developing human CNS, with focus on the cerebral neocortex, and the insights these findings provide into human neural evolution, function, and dysfunction.

References

Jun 1, 1977·Archives of Neurology·J G ChiF H Gilles
Oct 9, 1992·Science·N A O'RourkeS K McConnell
Sep 1, 1990·Brain Research. Developmental Brain Research·S J GouldL Papadaki
May 15, 1988·The Journal of Comparative Neurology·L MrzljakC G Van Eden
Aug 8, 1988·The Journal of Comparative Neurology·R M Napper, R J Harvey
May 29, 1987·Science·R W ThatcherS Giudice
Nov 1, 1985·Early Human Development·J I de VriesH F Prechtl
Jan 1, 1972·Developmental Psychobiology·B Amsterdam
Feb 28, 1973·Brain Research·M E MolliverH van der Loos
Mar 1, 1980·British Journal of Obstetrics and Gynaecology·L G Van Dongen, E G Goudie
Dec 1, 1994·Acta Paediatrica. Supplement·B Bogin
Jul 1, 1997·Pediatrics in Review·C P Johnson, P A Blasco
Jul 28, 1997·The Journal of Comparative Neurology·B Pakkenberg, H J Gundersen
Oct 23, 1997·The Journal of Comparative Neurology·P R Huttenlocher, A S Dabholkar
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Jan 1, 2003·Cerebral Cortex·Grethe Badsberg SamuelsenBente Pakkenberg
Apr 30, 2003·Journal of Neurobiology·Leonardo C deAzevedoRoberto Lent
Jun 10, 2003·The Journal of Comparative Neurology·Lisbeth MarnerBente Pakkenberg
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nitin GogtayPaul M Thompson
Jul 13, 2005·Cell·Kirsty L SpaldingJonas Frisén
Jul 19, 2005·Genome Research·Adam SiepelDavid Haussler
Jan 24, 2006·Current Opinion in Neurobiology·Brian G Rash, Elizabeth A Grove
Mar 7, 2006·Neuroscience·C C LarsenB Pakkenberg
Jun 20, 2006·Nature Neuroscience·Irina BystronColin Blakemore
Jul 22, 2006·Nature Reviews. Neuroscience·Tao Sun, Christopher A Walsh
Nov 4, 2006·Science·Shyam PrabhakarEdward M Rubin
Feb 7, 2007·Journal of Neuropathology and Experimental Neurology·Robert F Hevner
May 22, 2007·Nature Reviews. Neuroscience·Bradley J MolyneauxJeffrey D Macklis
Jun 7, 2007·Current Opinion in Psychiatry·Ronald C KesslerT Bedirhan Ustün
Jul 20, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hari EswaranCurtis L Lowery
Oct 7, 1977·Science·A N Meltzoff, M K Moore

❮ Previous
Next ❯

Citations

May 7, 2016·Nature Reviews. Neurology·Zoltán Molnár, Stephen Kennedy
Jun 4, 2016·Cell Stem Cell·Iva Kelava, Madeline A Lancaster
Jul 13, 2016·Developmental Biology·Iva Kelava, Madeline A Lancaster
Sep 16, 2016·Current Neurology and Neuroscience Reports·Marit W Vermunt, Menno P Creyghton
Jan 12, 2017·The Journal of Comparative Neurology·Jill R GlausierDavid A Lewis
May 13, 2017·Paediatric Anaesthesia·Soomin LeeYoungkwon Ko
Jul 4, 2017·Nature Communications·Denis Jabaudon
Mar 17, 2018·Nature Reviews. Neuroscience·Marc P ForrestPeter Penzes
Dec 12, 2017·Korean journal of anesthesiology·Woosuk ChungYong Sup Shin
Apr 25, 2018·Cerebral Cortex·Valentina CastiglioniElena Cattaneo
Nov 25, 2017·Frontiers in Neuroanatomy·Tatiana Popovitchenko, Mladen-Roko Rasin
Nov 24, 2017·Nature Reviews. Neuroscience·Giles E HardinghamHilmar Bading
Jan 16, 2018·Epigenomics·Emily Ma Lewis, Kristen L Kroll
Jul 10, 2018·Annual Review of Neuroscience·Ryan N DoanChristopher A Walsh
Jul 10, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ellen FritscheJulia Tigges
Aug 4, 2018·PLoS Biology·Jia Pei ChanDavid L Silver
Jun 21, 2018·Basic & Clinical Pharmacology & Toxicology·Marja-Leena Linne
Jan 4, 2019·Journal of Neuropathology and Experimental Neurology·Giovanni CirilloMichele Papa
Jan 25, 2018·Nature·Sergiu P Pașca
Feb 23, 2018·Nature·Carol M Worthman, Kathy Trang
Mar 31, 2019·Schizophrenia Bulletin·Long-Biao CuiMartijn P Van den Heuvel
Aug 3, 2018·Development and Psychopathology·Bea R H van den BerghMaarten Mennes
Feb 17, 2018·Nature Reviews. Neuroscience·John H GilmoreWei Gao
Aug 3, 2019·Journal of Anatomy·Zoltán MolnárArnold Kriegstein
Apr 5, 2018·The EMBO Journal·Marc Segarra-MondejarFrancesc X Soriano
Jul 12, 2019·The British Journal of Radiology·Leo P Sugrue, Rahul S Desikan
Nov 10, 2017·FEBS Letters·Robert Beattie, Simon Hippenmeyer
Nov 23, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Diego GuidolinCinzia Tortorella
Sep 10, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dongdong ChaiHong Jiang
Jun 8, 2019·Journal of Anatomy·Noemi PiccoThomas E Woolley
Feb 16, 2020·Brain Structure & Function·Muriel M K BruchhageSean C L Deoni
Jun 13, 2020·Critical Reviews in Toxicology·Deepika DeepikaVikas Kumar
Jul 2, 2020·Experimental Neurobiology·Tae-Young LeeHaeyoung Suh-Kim
Aug 25, 2020·Interdisciplinary Sciences, Computational Life Sciences·Jiayidaer BadaiLe Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Related Papers

Frontiers in Molecular Neuroscience
Timothy J PetrosStewart A Anderson
Anatomy Research International
A E EvansA E Rosser
Current Opinion in Gastroenterology
Andrew B ShreinerVincent B Young
BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Lorelei D Shoemaker, Paola Arlotta
© 2022 Meta ULC. All rights reserved