The cellular basis for interaction of sterility factors in the mouse t haplotype

Genetical Research
L R JohnsonP Olds-Clarke

Abstract

The t haplotypes are variant forms of the proximal one-third of chromosome 17 in the mouse. They contain four inversions (relative to the wildtype DNA) extending over most of this region and house a number of male sterility factors. Males carrying two complete t haplotypes (t/t) are sterile, as are males homozygous for S2, the sterility factor located in the most distal (relative to the centromere) inversion. Males homozygous for the sterility factor S1, located in the most proximal inversion, are not sterile; however, if such a male also is heterozygous for other sterility factors, then sterility results. It has been suggested therefore that homozygosity for S1 enhances the detrimental action of other sterility factors. Sperm from t/t males have severe motility defects and are unable to penetrate investment-free eggs, while sperm from fertile t/+ mice have less serious motility defects and exhibit a delay in penetration of investment-free eggs. To determine whether homozygosity for S1 enhances the cellular defects exhibited by sperm from mice heterozygous for other sterility factors, we compared the motility and egg-penetrating ability of sperm from fertile mice homozygous for S1 to that of sperm from mice carrying one complet...Continue Reading

References

Feb 1, 1987·Developmental Biology·L M SilverN B Hecht
Jun 1, 1967·Journal of Reproduction and Fertility·D Bennett, L C Dunn
Jul 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J K DosikB A Mock
Jan 1, 1993·Developmental Biology·P Olds-Clarke, L R Johnson

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Citations

Mar 7, 2002·Theoretical Population Biology·M van Boven, F J Weissing
Dec 1, 1996·Evolution; International Journal of Organic Evolution·Michiel van BovenJef Huisman

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