PMID: 9548016Apr 21, 1998Paper

The cellular biology of B-cell chronic lymphocytic leukemia

Critical Reviews in Oncology/hematology
J Jurlander

Abstract

In conclusion, B-CLL cells through their immunophenotype have the functional potential required to interact with cells in what has been called the immunological synapse, i.e. the cognate interactions between T-cells, antigen-presenting cells and B-cells during immunopoiesis. The data reviewed herein provides substantial evidence to suggest that B-CLL cells in fact can interact, not only with T-cells but also with endothelial cells and stromal cells in the bone marrow. These interactions, in particular signaling through CD40, contribute to extended survival and proliferation of B-CLL cells and, thereby, the risk of complete malignant transformation of the clone. Therefore, this review would suggest that the answers to how B-CLL is initiated may be found in molecules responsible for the normal regulation of immunopoiesis. Transformation to malignancy, by contrast, is likely to be caused by loss of control over the G1 restriction in the cell cycle in B-CLL cells.

References

Jun 1, 1976·British Journal of Haematology·D CatovskyD A Galton
Feb 1, 1992·The Journal of Experimental Medicine·D AderkaD Wallach
Apr 1, 1992·Genes, Chromosomes & Cancer·Y LiuS Einhorn
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K E BurgessC E Rudd
Aug 6, 1992·Nature·J P AubryJ Y Bonnefoy
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A AruffoI Stamenkovic
Apr 1, 1992·The Journal of Clinical Investigation·S FournierM Sarfati
Apr 1, 1992·British Journal of Haematology·J P KremerP Dörmer
Jun 20, 1991·Nature·H Van de VeldeK Thielemans
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J F Bazan
Sep 13, 1990·The New England Journal of Medicine·G JuliussonG Gahrton
Jan 1, 1989·The Journal of Experimental Medicine·Z M SthoegerN Chiorazzi
Feb 1, 1989·European Journal of Immunology·T DefranceJ Banchereau
Oct 1, 1988·Journal of Autoimmunity·B M BrökerP Collins
Jan 1, 1988·The Journal of Experimental Medicine·J Y BonnefoyJ Banchereau
Jul 1, 1988·The Journal of Experimental Medicine·S KarrayP Galanaud
Feb 1, 1982·The Journal of Experimental Medicine·F Caligaris-CappioG Janossy
Apr 1, 1994·European Journal of Immunology·A C LankesterR A van Lier
May 1, 1994·Stem Cells·J BanchereauF Rousset
Sep 1, 1994·Immunology Today·F H DurieR J Noelle
Sep 1, 1994·Immunology Today·T F TedderP Engel
Sep 1, 1994·Immunology Today·T F Tedder, P Engel
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell

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Citations

Aug 31, 2002·Hematological Oncology·Gerassimos A PangalisMaria K Angelopoulou
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·M S GordonD J Rawlings
Jun 20, 2015·Respirology Case Reports·Miranda MawJonathan Williamson
Dec 29, 2004·Leukemia & Lymphoma·Irene Munk Pedersen, John Reed
Jan 24, 2004·Leukemia & Lymphoma·Montserrat BarragánJoan Gil
Oct 23, 2004·International Journal of Cancer. Journal International Du Cancer·Alejo A MoralesLyda M Osorio
Nov 2, 2007·Leukemia·A G S BugginsS Devereux
Dec 26, 2001·Leukemia·R GamberaleM Giordano
May 27, 2010·International Journal of Cancer. Journal International Du Cancer·Huseyin Atakan Ekiz, Yusuf Baran
Mar 27, 2003·European Journal of Haematology·Davide RapezziGian Franco Gaetani
Jul 20, 2016·International Journal of Oncology·Xiaoling LiuRenxi Wang
Feb 13, 2003·British Journal of Haematology·William G WierdaMaher Albitar

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