PMID: 1193423Sep 1, 1975Paper

The cellular infiltrate of the jejunum in adult coeliac disease and dermatitis herpetiformis following the reintroduction of dietary gluten

Gut
M Lancaster-SmithA M Dawson

Abstract

The cellular infiltrate of the jejunal mucosa has been studied in patients with both treated and untreated adult coeliac disease and dermatitis herpetiformis and serially in treated patients before and after the reintroduction of gluten to the diet. In adult coeliac disease and dermatitis herpetiformis the jejunal mucosa showed similar abnormalities of the cellular infiltrate which was characterized by an increase in intraepithelial lymphocytes and lamina propria plasma cells and eosinophils, with the greatest numbers of cells occurring in untreated patients. At 24-48 hours following a single 25-g gluten challenge there was an increase in lamina propria plasma cells, lymphocytes and eosinophils and intraepithelial lymphocytes. This rise was sustained after seven days on a gluten-containing diet for all of these cell groups except lamina propria lymphocytes. These responses were essentially similar in both adult coeliac disease and in those dermatitis herpetiformis patients who had jejunal lesions before treatment. In dermatitis herpetiformis patients with normal jejunal morphology on a normal diet there was an upward trend in lamina propria plasma cells and intraepithelial lymphocytes within one to three weeks of taking extra d...Continue Reading

References

Sep 28, 1974·Lancet·M J Lancaster-SmithG D Johnson
Feb 1, 1974·American Journal of Public Health·M A Pond
Dec 1, 1970·The British Journal of Dermatology·N G Fraser
Jan 1, 1970·International Archives of Allergy and Applied Immunology·A B KayR R Coombs
Aug 12, 1972·British Medical Journal·L FryA V Hoffbrand

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Citations

Jan 1, 1996·Surgery Today·N TanakaK Hao
May 1, 1980·European Journal of Pediatrics·M J Brueton
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Feb 1, 1978·The Journal of Investigative Dermatology·S I Katz, W Strober

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