The cellular organization of gene expression

Current Opinion in Cell Biology
T Misteli, D L Spector

Abstract

Recent cell biological observations have provided new insights into how transcription, pre-mRNA splicing and 3' processing are organized and coordinated with each other in the mammalian cell nucleus. Morphological observations are supported by biochemical evidence that suggests physical interactions between components of the transcription and RNA processing machineries. A working model of the cellular organization of gene expression is now emerging.

References

Oct 1, 1992·Experimental Cell Research·K Brasch, R L Ochs
May 1, 1992·Genes & Development·A M ZahlerM B Roth
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ Gray
Dec 23, 1988·Science·J Borden, L Manuelidis
May 1, 1969·Journal of Ultrastructure Research·A Monneron, W Bernhard
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L Manuelidis
Jan 1, 1995·Journal of Virology·E BridgeU Pettersson
Dec 22, 1994·Nature·G ZhangM R Green
Sep 1, 1994·Experimental Cell Research·S KrauseE Wahle
Mar 1, 1994·Trends in Genetics : TIG·D S Horowitz, A R Krainer
Jan 1, 1993·Annual Review of Cell Biology·D L Spector
Apr 1, 1993·Trends in Biochemical Sciences·A L Greenleaf
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·M L HedleyT Maniatis
May 3, 1996·Science·J M LaSalle, M Lalande
Jan 1, 1995·Journal of Cell Science. Supplement·J D LewisI W Mattaj
Jul 1, 1996·Genes & Development·J L Manley, R Tacke
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·A YuryevJ L Corden
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M J MortillaroR Berezney
Aug 9, 1996·The Journal of Biological Chemistry·M E Dahmus

❮ Previous
Next ❯

Citations

Jun 8, 2000·Microscopy Research and Technique·C Zeng
Jan 19, 2002·Biochemical and Biophysical Research Communications·Peter StoilovStefan Stamm
Jan 1, 2013·Cell and Tissue Research·Irina BogolyubovaDmitry Bogolyubov
Dec 23, 2004·Journal of Molecular Histology·Silvia GaragnaMaurizio Zuccotti
May 19, 2004·The International Journal of Biochemistry & Cell Biology·Laura VerganiClaudio Nicolini
Apr 20, 2005·Molecular and Cellular Endocrinology·Maurizio ZuccottiCarlo Alberto Redi
Jun 8, 2002·Biochemical and Biophysical Research Communications·Ping WangPin Ouyang
Jul 25, 2003·Experimental Cell Research·Katherine L DunnJames R Davie
Apr 23, 2003·Molecular and Biochemical Parasitology·Martín VázquezMariano J Levin
Sep 6, 2003·Gene·Marta AlvarezJoseph P Bidwell
Jul 8, 1999·Current Opinion in Cell Biology·A S BelmontT Tumbar
Jul 8, 1999·Current Opinion in Cell Biology·J E Sleeman, A I Lamond
Dec 20, 2002·Journal of Structural Biology·Olivia DoyleJoseph G Gall
Aug 2, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Joshua Z Gasiorowski, David A Dean
Sep 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·James R Boyne, Adrian Whitehouse
Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Gerald DonnertStefan W Hell
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·J R Sanford, J P Bruzik
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·T KuesU Kubitscheck
Oct 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·I-Fan WangC-K James Shen
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·C G BurnsK L Gould
Jun 8, 1999·Molecular Biology of the Cell·M J HendzelD P Bazett-Jones
Dec 5, 2000·Molecular Biology of the Cell·M D Hebert, A G Matera
Feb 26, 2000·Molecular Biology of the Cell·R EilsT Misteli
Feb 11, 2005·Molecular Biology of the Cell·Indumathi Mariappan, Veena K Parnaik
Jun 1, 2004·Molecular Biology of the Cell·Noriko SaitohDavid L Spector
May 15, 2001·The EMBO Journal·I WetterbergU Skoglund
Apr 25, 2000·Nucleic Acids Research·M N Szentirmay, M Sawadogo
Dec 6, 2002·Nucleic Acids Research·Gaute BredeHans Prydz
Mar 3, 2005·Nucleic Acids Research·Steven J KavanaghPeter D Rathjen
Sep 26, 2000·Human Molecular Genetics·N A LittleR C Davies

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.