The cellularity of offspring's adipose tissue is programmed by maternal nutritional manipulations

Adipocyte
Simon Lecoutre, Christophe Breton

Abstract

Epidemiological studies initially demonstrated that maternal undernutrition leads to low birth weight with increased risk of adult-onset obesity. Maternal obesity and diabetes associated with high birth weight, excessive nutrition in neonates, and rapid catch-up growth also predispose offspring to fat accumulation. As stated by the Developmental Origin of Health and Disease concept, nutrient supply perturbations in the fetus or neonate result in long-term programming of individual body weight set-point. Adipose tissue is a key fuel storage unit mainly involved in the maintenance of energy homeostasis. Studies in numerous animal models have demonstrated that the adipose tissue is the focus of developmental programming events in a gender- and depot-specific manner. This review summarizes the impact of maternal nutritional manipulations on cellularity (i.e., cell number, size, and type) of adipose tissue in programmed offspring. In rodents, adipose tissue development is particularly active during the perinatal period, especially during the last week of gestation and during early postnatal life. In contrast to rodents, this process essentially takes place before birth in bigger mammals. Despite these different developmental time wi...Continue Reading

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Citations

Jun 2, 2015·Frontiers in Physiology·Simon Lecoutre, Christophe Breton
Apr 29, 2016·The Journal of Endocrinology·Simon LecoutreChristophe Breton
Mar 3, 2020·Nutrition Research Reviews·Ericka Moreno-MendezMaria-Luisa Lazo-de-la-Vega-Monroy
Mar 7, 2020·International Journal of Environmental Research and Public Health·Mei-Hsin HsuLi-Tung Huang
Jan 4, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Simon LecoutreChristophe Breton
May 13, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Lindsay EllsworthBrigid Gregg
Jun 2, 2020·Current Genomics·Simon LecoutreChristophe Breton
Jan 4, 2017·The Journal of Clinical Investigation·Kanakadurga Singer, Carey N Lumeng
Nov 18, 2018·Nutrition Reviews·Rafael BarraAlejandro Hernández
Apr 24, 2021·World Journal of Diabetes·Simon LecoutreChristophe Breton
Aug 11, 2021·Nutrients·Isabela Monique FortunatoMarcelo Lima Ribeiro

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