The center of the emotional universe: Alcohol, stress, and CRF1 amygdala circuitry.

Alcohol
Abigail E Agoglia, Melissa A Herman

Abstract

The commonalities between different phases of stress and alcohol use as well as the high comorbidity between alcohol use disorders (AUDs) and anxiety disorders suggest common underlying cellular mechanisms governing the rewarding and aversive aspects of these related conditions. As an integrative center that assigns emotional salience to a wide variety of internal and external stimuli, the amygdala complex plays a major role in how alcohol and stress influence cellular physiology to produce disordered behavior. Previous work has illustrated the broad role of the amygdala in alcohol, stress, and anxiety. However, the challenge of current and future studies is to identify the specific dysregulations that occur within distinct amygdala circuits and subpopulations and the commonalities between these alterations in each disorder, with the long-term goal of identifying potential targets for therapeutic intervention. Specific intra-amygdala circuits and cell type-specific subpopulations are emerging as critical targets for stress- and alcohol-induced plasticity, chief among them the corticotropin releasing factor (CRF) and CRF receptor 1 (CRF1) system. CRF and CRF1 have been implicated in the effects of alcohol in several amygdala nuc...Continue Reading

Citations

Nov 30, 2019·Alcoholism, Clinical and Experimental Research·A Leslie MorrowPatrizia Porcu
Jul 9, 2020·Addiction Biology·Antonio Jesús López-GamberoJuan Suárez
Dec 9, 2020·Molecular Psychiatry·Carina CarbiaJohn F Cryan
May 4, 2020·Neuroscience and Biobehavioral Reviews·Marjorie C Gondré-LewisKenneth Blum
Jan 27, 2021·Clinical Psychology Review·Séverine LannoyPierre Maurage
Jun 3, 2021·Biomolecules·Goran ŠimićPatrick R Hof

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