The Central Bright Spot Sign: A Potential New MR Imaging Sign for the Early Diagnosis of Anterior Ischemic Optic Neuropathy due to Giant Cell Arteritis.

AJNR. American Journal of Neuroradiology
P RemondC Chiquet

Abstract

A rapid identification of the etiology of anterior ischemic optic neuropathy is crucial because it determines therapeutic management. Our aim was to assess MR imaging to study the optic nerve head in patients referred with anterior ischemic optic neuropathy, due to either giant cell arteritis or the nonarteritic form of the disease, compared with healthy subjects. Fifteen patients with giant cell arteritis-related anterior ischemic optic neuropathy and 15 patients with nonarteritic anterior ischemic optic neuropathy from 2 medical centers were prospectively included in our study between August 2015 and May 2016. Fifteen healthy subjects and patients had undergone contrast-enhanced, flow-compensated, 3D T1-weighted MR imaging. The bright spot sign was defined as optic nerve head enhancement with a 3-grade ranking system. Two radiologists and 1 ophthalmologist independently performed blinded evaluations of MR imaging sequences with this scale. Statistical analysis included interobserver agreement. MR imaging scores were significantly higher in patients with giant cell arteritis-related anterior ischemic optic neuropathy than in patients with nonarteritic anterior ischemic optic neuropathy (P ≤ .05). All patients with giant cell a...Continue Reading

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Citations

Jan 3, 2018·Journal of Magnetic Resonance Imaging : JMRI·Arnaud AttyéAlexandre Krainik
Oct 5, 2019·Continuum : Lifelong Learning in Neurology·Mark J Morrow
Jul 31, 2019·BMC Geriatrics·Miguel Á González-GayNorberto Ortego-Centeno
Jan 27, 2020·Progress in Retinal and Eye Research·Eun Jung LeeChangwon Kee
Jul 21, 2021·The British Journal of Ophthalmology·Valentina Daphne PetrouliaFranca Wagner
Sep 29, 2021·Indian Journal of Ophthalmology·Chinmay P NageshSantosh G Honavar

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