The central circulation in congestive heart failure non-invasively evaluated with dynamic positron emission tomography

Clinical Physiology and Functional Imaging
Jens SörensenGöran Hedenstierna

Abstract

Positron emission tomography (PET) with [15O]-H2O-PET (WAT-PET) or [11C]-acetate (AC-PET) quantifies myocardial perfusion and oxidative metabolism, but routine clinical use is hampered by the need for additional investigations to assess cardiac performance. To apply classical tracer kinetics to dynamic PET could provide important haemodynamic parameters. First-pass PET data were used with indicator dilution techniques to measure stroke volume index (SVI). Early pulmonary retention of [11C]-acetate was converted to standard uptake values (SUV) (Lung(AC-SUV)). Regional lung water (rLW) content was computed from the WAT-PET scan at equilibrium. PET was compared with radionuclide angiography and echocardiography in patients with ischaemic cardiomyopathy with New York Heart Association class II (n = 10) or III (n = 18) congestive heart failure. Elderly male volunteers without heart disease (n = 11) underwent AC-PET as controls. SVI with both tracers correlated in patients (r = 0.91, P<0.001, estimated standard error = 4 ml m(-2)) and with left ventricular ejection fraction (both tracers r>0.6, P<0.001). SVI was significantly different between all groups (ANOVA: P<0.001). Lung(AC-SUV) correlated with rLW (r = 0.78, P<0.001) and both ...Continue Reading

References

May 1, 1997·European Heart Journal·E Braunwald
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·N R Lange, D P Schuster
May 4, 2001·The American Journal of Medicine·E J Eichhorn
Jun 1, 2001·European Journal of Nuclear Medicine·L J KleinA A Lammertsma
May 17, 2002·Current Opinion in Cardiology·Meeney Dhir, Sherif F Nagueh

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Citations

Apr 24, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Orjan LindheJens Sörensen
Mar 29, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Paul KnaapenAdriaan A Lammertsma
Apr 10, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mouaz H Al-MallahSharmila Dorbala

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