PMID: 7018703Jun 1, 1981Paper

The central dogma of cell biology

Cell Biology International Reports
S Cooper

Abstract

The Continuum Model proposes that preparations for DNA synthesis occur continuously during all phases of the division cycle. Various stimuli activate cell proliferation by changing the rate of initiator (protein) synthesis. Cell division does not initiate any process regulating cell proliferation. Cell division is the end of a process and the beginning of nothing. The alternative model which has cell proliferation regulated in the G1 phase of the division cycle is reexamined and the two types of evidence for this model, G1-variability and G1-arrest are shown to be compatible with the Continuum Model. Here, the Continuum Model is generalized to produce a new look at the logic of the division cycle in prokaryotes and eukaryotes. This new view, the Central Dogma of Cell Biology, is presented and two predictions are made. I propose that (i) cell division does not have any regulatory function, and (ii) that DNA synthesis may, indeed, have some affect on the synthesis of initiator.

Citations

Mar 20, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S Cooper
Jun 7, 2008·Journal of Biosciences·Michel Morange
Apr 1, 1984·Journal of Cellular Physiology·P N RaoY C Wang
Jan 1, 1990·Research in Microbiology·S Cooper
Feb 21, 1982·Journal of Theoretical Biology·S Cooper
Oct 5, 2021·Frontiers in Cell and Developmental Biology·Kailing PanWenxia Xu

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