The central nervous effect of prostaglandins I2, E2 and F2 alpha on aconitine-induced cardiac arrhythmia in rats

H J Mest, W Förster


Intracerebroventricular administration of PGI2 or PGE2 reduced aconitine-induced cardiac arrhythmia in rats. PGF2 alpha had no antiarrhythmic effect under the same conditions. The ED50 values of PGI2 and E2 were 0.25 microgram/kg and 1.1 microgram/kg, respectively. Central mechanisms may participate in the antiarrhythmic effect of these PGs.


Jan 1, 1977·Pharmacology·A Bodzenta, K Wisniewski
Mar 1, 1973·European Journal of Pharmacology·S BergströmK Fuxe
Mar 1, 1971·British Journal of Pharmacology·H A LaveryG C Scroop


Dec 2, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Yan LiuBao-Feng Yang
Apr 23, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Wei HuangHong-li Sun
Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H J Mest, J Rausch
Oct 23, 2013·Canadian Journal of Physiology and Pharmacology·Fan ChenHong-li Sun
Nov 1, 1981·Neuropharmacology·G FeuersteinD M Jacobowitz
Nov 1, 1981·Prostaglandins and Medicine·H J Mest, W Förster
Sep 2, 2009·Journal of Cardiovascular Pharmacology and Therapeutics·Wei-ming ZhaoYan Liu

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