The central nervous stimulating effect of four different halogenated ether anesthetics and halothane in mice

Journal of Anesthesia
H KomatsuK Ogli

Abstract

Although enflurane is a convulsive anesthetic, its structural isomer, isoflurane, is believed not to be. We reported previously that, unexpectedly, isoflurane more frequently produced opisthotonus in young mice, especially during the induction period, than enflurane. In the present study, we examined the incidences of opisthotonus induced by four halogenated ether anesthetics and halothane to evaluate their CNS stimulating actions. As experimental animals, we used young male mice, with another two aged groups of male mice to clarify the relationship of the incidence of opisthotonus to aging. The percentage incidence of opisthotonus was 93% for sevoflurane, 81% for isoflurane, 64% for enflurane, 17% for methoxyflurane and 2% for halothane. These results suggest that the halogenated ether anesthetic, which is rapidly uptaken by the CNS during induction, is more likely to produce CNS stimulation, subsequently leading to opisthotonus. There was no age related susceptibility difference to anesthetic-induced opisthotonus, except for enflurane, in which the incidence of opisthotonus was higher in the aged group.

References

Mar 1, 1974·British Journal of Anaesthesia·F G Rudo, J C Krantz
Jul 1, 1974·Anesthesiology·R J PalahniukE I Eger
Oct 26, 1981·Brain Research·M BaudryG Lynch
Nov 1, 1981·Anesthesiology·E I Eger

❮ Previous
Next ❯

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Kathryn A SalvatiMark P Beenhakker

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.